Evidence map›Paper›PMID 34074747›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Genetic and molecular determinants of polymicrobial interactions in

Chenggang Wu, Yi-Wei Chen, Matthew Scheible, Chungyu Chang, Manuel Wittchen, Ju Huck Lee, Truc T Luong, Bethany L Tiner, Andreas Tauch, Asis Das and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 73 citations in OpenAlex.

  1. The role of adhesins ofGut microbes · 2026
    Review
  2. Review
  3. RadD fromeLife · 2026
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  6. MedComm · 2025
    Review
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  8. Identifying essential genes inJournal of bacteriology · 2025
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  9. Journal of bacteriology · 2025
    Review
  10. Article
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  13. Inactivation of thebioRxiv : the preprint server for biology · 2025
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  14. Review
  15. Development of a conditional plasmid for gene deletion in non-modelApplied and environmental microbiology · 2025
    Article
  16. Article
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  19. Article
  20. Ethanolamine-induced assembly of microcompartments is required forbioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Chenggang WuDepartment of Microbiology and Molecular Genetics, University of Texas Health Science Center, Houston, TX 77030; Chenggang.Wu@uth.tmc.edu Adas@uchc.edu htonthat@dentistry.ucla.edu.ORCID 0000-0002-5700-7188
Yi-Wei ChenDivision of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, CA 90024.
Matthew ScheibleDivision of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, CA 90024.
Chungyu ChangDivision of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, CA 90024.ORCID 0000-0001-6127-3086
Manuel WittchenCenter for Biotechnology, Bielefeld University, D-33501 Bielefeld, Germany.
Ju Huck LeeKorean Collection for Type Cultures, Korea Research Institute of Bioscience and Biotechnology, Jeollabuk-do 56212, Republic of Korea.ORCID 0000-0001-6103-7593
Truc T LuongDivision of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, CA 90024.ORCID 0000-0001-7355-8388
Bethany L TinerDepartment of Microbiology and Molecular Genetics, University of Texas Health Science Center, Houston, TX 77030.
Andreas TauchCenter for Biotechnology, Bielefeld University, D-33501 Bielefeld, Germany.
Asis DasDepartment of Medicine, Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, CT 06030; Chenggang.Wu@uth.tmc.edu Adas@uchc.edu htonthat@dentistry.ucla.edu.
Hung Ton-ThatDivision of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, CA 90024; Chenggang.Wu@uth.tmc.edu Adas@uchc.edu htonthat@dentistry.ucla.edu.ORCID 0000-0003-1611-0469
University of California, Los Angeles · USBielefeld University · DEThe University of Texas Health Science Center at Houston · USKorea Research Institute of Bioscience and Biotechnology · KRUConn Health · US

Funding

Molecular Assembly on the Cell Surface of ActinomycesR01DE017382 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Hung Ton-That · 2008 to 2026
$6.7M
Virulence determinants of Fusobacterium nucleatumR01DE026758 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TON-THAT, HUNG · 2017 to 2021
$2.0M
Molecular mechanisms of polymicrobial interactions in Fusobacterium nucleatumR21DE026574 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI WU, CHENGGANG · 2017 to 2018
$424k
NIDCR NIH HHS R01 DE017382NIDCR NIH HHS R01 DE026758NIDCR NIH HHS R21 DE026574
6 · The paper itself

Abstract

A gram-negative colonizer of the oral cavity,

Indexed as

Bacterial ProteinsFusobacterium InfectionsFusobacterium nucleatumVirulence FactorsAnimalsGenome-Wide Association StudyHumansMicePremature BirthSignal TransductionBacterial ProteinsVirulence FactorscoaggregationFusobacterium nucleatumpreterm birthtwo-component transduction systemvirulence

Identifiers

PMID34074747
PMCPMC8201914
OpenAlexW3165845373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.