Evidence map›Paper›PMID 34074746›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Temporal regulation of nicotinic acetylcholine receptor subunits supports central cholinergic synapse development in

Justin S Rosenthal, Jun Yin, Jingce Lei, Anupama Sathyamurthy, Jacob Short, Caixia Long, Emma Spillman, Chengyu Sheng, Quan Yuan

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Molecular organization of central cholinergic synapses.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Review
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  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Justin S RosenthalNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892.ORCID 0000-0002-6126-4478
Jun YinNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892.ORCID 0000-0003-4314-4402
Jingce LeiNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892.
Anupama SathyamurthyNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892.
Jacob ShortNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892.ORCID 0000-0002-5740-3535
Caixia LongNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892.
Emma SpillmanNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892.
Chengyu ShengNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892.ORCID 0000-0002-7352-4871
Quan YuanNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892; quan.yuan@nih.gov.ORCID 0000-0002-0676-2079
National Institute of Neurological Disorders and Stroke · US

Funding

Study dendrite morphogenesis and activity-dependent plasticity using DrosophilaZIANS003137 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI YUAN, QUAN · 2013 to 2025
$24.9M
Intramural NIH HHS ZIA NS003137
6 · The paper itself

Abstract

The construction and maturation of the postsynaptic apparatus are crucial for synapse and dendrite development. The fundamental mechanisms underlying these processes are most often studied in glutamatergic central synapses in vertebrates. Whether the same principles apply to excitatory cholinergic synapses, such as those found in the insect central nervous system, is not known. To address this question, we investigated a group of projection neurons in the

Indexed as

MorphogenesisSynaptic TransmissionAnimalsCholinergic NeuronsDendritesDrosophila melanogasterDrosophila ProteinsLarvaReceptors, NicotinicSynapsesDrosophila ProteinsReceptors, Nicotiniccholinergic transmissiondendrite morphogenesisnAchR subunitssynapse developmenttranscriptional regulation

Identifiers

PMID34074746
PMCPMC8202021
OpenAlexW3165038566

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.