Evidence map›Paper›PMID 34074729›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2021

BCRP/

Xia Wen, Danielle Kozlosky, Ranran Zhang, Cathleen Doherty, Brian Buckley, Emily Barrett, Lauren M Aleksunes

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Cadmium transport by mammalian ATP-binding cassette transporters.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xia WenDepartment of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, New Jersey (X.W., D.K., L.M.A.); Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, New Jersey (X.W., R.Z., C.D., B.B., E.B., L.M.A.); and Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey (R.Z., E.B.).
Danielle KozloskyDepartment of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, New Jersey (X.W., D.K., L.M.A.); Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, New Jersey (X.W., R.Z., C.D., B.B., E.B., L.M.A.); and Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey (R.Z., E.B.).
Ranran ZhangDepartment of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, New Jersey (X.W., D.K., L.M.A.); Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, New Jersey (X.W., R.Z., C.D., B.B., E.B., L.M.A.); and Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey (R.Z., E.B.).
Cathleen DohertyDepartment of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, New Jersey (X.W., D.K., L.M.A.); Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, New Jersey (X.W., R.Z., C.D., B.B., E.B., L.M.A.); and Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey (R.Z., E.B.).
Brian BuckleyDepartment of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, New Jersey (X.W., D.K., L.M.A.); Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, New Jersey (X.W., R.Z., C.D., B.B., E.B., L.M.A.); and Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey (R.Z., E.B.).
Emily BarrettDepartment of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, New Jersey (X.W., D.K., L.M.A.); Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, New Jersey (X.W., R.Z., C.D., B.B., E.B., L.M.A.); and Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey (R.Z., E.B.).
Lauren M AleksunesDepartment of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, New Jersey (X.W., D.K., L.M.A.); Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, New Jersey (X.W., R.Z., C.D., B.B., E.B., L.M.A.); and Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey (R.Z., E.B.) aleksunes@eohsi.rutgers.edu.
Rutgers, The State University of New Jersey · USEnvironmental and Occupational Health Sciences Institute · US

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Emily S Barrett · 1988 to 2026
$47.4M
New Jersey Alliance for Clinical Translational Science: NJ ACTSUL1TR003017 · NCATS · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI PANETTIERI, REYNOLD ALEXANDER · 2019 to 2023
$28.9M
TRAINING IN EVIRONMENTAL TOXICOLOGYT32ES007148 · NIEHS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI Lauren M Aleksunes · 1987 to 2026
$11.4M
Placental Responses to Environmental Chemicals - Diversity Supplement 2R01ES029275 · NIEHS · RUTGERS, THE STATE UNIV OF N.J. · PI ALEKSUNES, LAUREN M, BARRETT, EMILY S · 2018 to 2022
$3.2M
Impact of the Placenta Barrier on Fetal Nutrition and Growth RestrictionF31ES032319 · NIEHS · RUTGERS, THE STATE UNIV OF N.J. · PI KOZLOSKY, DANIELLE · 2020 to 2022
$123k
NCATS NIH HHS UL1 TR003017NIEHS NIH HHS F31 ES032319NIEHS NIH HHS P30 ES005022NIEHS NIH HHS R01 ES029275NIEHS NIH HHS T32 ES007148
6 · The paper itself

Abstract

Exposure to the environmental pollutant cadmium is ubiquitous, as it is present in cigarette smoke and the food supply. Over time, cadmium enters and accumulates in the kidneys, where it causes tubular injury. The breast cancer resistance protein (BCRP, ATP-Binding Cassette G2

Indexed as

ATP Binding Cassette Transporter, Subfamily G, Member 2KidneyNeoplasm ProteinsAnimalsApoptosisBiological Transport, ActiveCadmiumHEK293 CellsHumansMiceMice, KnockoutPolymorphism, Single NucleotideProtective FactorsRenal EliminationABCG2 protein, humanAbcg2 protein, mouseATP Binding Cassette Transporter, Subfamily G, Member 2CadmiumNeoplasm Proteins

Identifiers

PMID34074729
PMCPMC8382159
OpenAlexW3164181803

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.