Evidence map›Paper›PMID 34074703›Full record

ArticleScience signaling2021

Respiratory syncytial virus induces β

Terri J Harford, Fariba Rezaee, Manveen K Gupta, Vladimir Bokun, Sathyamangla V Naga Prasad, Giovanni Piedimonte

Abstract read
In one paragraph

Article in Science signaling, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. The usual suspects: Respiratory syncytial virus and rhinovirus drive asthma development and exacerbation.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2025
    Review
  2. Article
  3. Update on the Role of β2AR and TRPV1 in Respiratory Diseases.International journal of molecular sciences · 2024
    Review
  4. Article
  5. In silico identification of a βProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  6. Article
  7. Review
  8. N-Acetyl-L-Cysteine Protects Airway Epithelial Cells duringAnalytical cellular pathology (Amsterdam) · 2022
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Terri J HarfordDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.ORCID 0000-0001-6590-0673
Fariba RezaeeDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Manveen K GuptaDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Vladimir BokunDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.ORCID 0000-0001-5796-0799
Sathyamangla V Naga PrasadDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.ORCID 0000-0003-3984-3788
Giovanni PiedimonteDepartments of Pediatrics, Biochemistry and Molecular Biology, Tulane School of Medicine, New Orleans, LA 70112, USA. gpiedimonte@tulane.edu.ORCID 0000-0003-1640-1928

Funding

NEUROGENIC INFLAMMATORY RESPONSE TO RSVR01HL061007 · NHLBI · WEST VIRGINIA UNIVERSITY · PI PIEDIMONTE, GIOVANNI · 1999 to 2022
$7.2M
Mechanisms of Airway Epithelial Barrier Dysfunction by Respiratory Syncytial Virus and Environmental StimuliR01HL148057 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI REZAEE, FARIBA · 2019 to 2023
$2.2M
Beta adrenergic receptor resensitization in asthmaR01HL127602 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI PRASAD, SATHYAMANGLA V · 2016 to 2019
$1.6M
Airway Epithelial Barrier Dysfunction In Response to Respiratory Syncytial VirusK08AI112781 · NIAID · UNIVERSITY OF ROCHESTER · PI REZAEE, FARIBA · 2015 to 2018
$734k
NHLBI NIH HHS R01 HL061007NHLBI NIH HHS R01 HL127602NHLBI NIH HHS R01 HL148057NIAID NIH HHS K08 AI112781
6 · The paper itself

Abstract

Pharmacologic agonism of the β

Indexed as

AsthmaRespiratory Syncytial VirusesChildCyclic AMPHumansLungMyocytes, Smooth MuscleCyclic AMP

Identifiers

PMID34074703
PMCPMC8486349

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.