Evidence map›Paper›PMID 34074696›Full record

ReviewGenes & development2021

Features and mechanisms of canonical and noncanonical genomic imprinting.

Courtney W Hanna, Gavin Kelsey

Open access · diamondAbstract readReview
In one paragraph

Review in Genes & development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Allele-specific methylation ofScience advances · 2026
    Article
  4. Review
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  7. Article
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  14. Polycomb function in early mouse development.Cell death and differentiation · 2025
    Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Courtney W HannaEpigenetics Programme, Babraham Institute, Cambridge CB22 3AT, United Kingdom.ORCID 0000-0002-4063-5575
Gavin KelseyEpigenetics Programme, Babraham Institute, Cambridge CB22 3AT, United Kingdom.ORCID 0000-0002-9762-5634
Babraham Institute · GB

Funding

Biotechnology and Biological Sciences Research Council BBS/E/B/000C0423Medical Research Council MR/S000437/1
6 · The paper itself

Abstract

Genomic imprinting is the monoallelic expression of a gene based on parent of origin and is a consequence of differential epigenetic marking between the male and female germlines. Canonically, genomic imprinting is mediated by allelic DNA methylation. However, recently it has been shown that maternal H3K27me3 can result in DNA methylation-independent imprinting, termed "noncanonical imprinting." In this review, we compare and contrast what is currently known about the underlying mechanisms, the role of endogenous retroviral elements, and the conservation of canonical and noncanonical genomic imprinting.

Indexed as

DNA MethylationEpigenomicsGenomic ImprintingHumansRetroelementsRetroelementschromatinDNA methylationendogenous retrovirusesepigeneticsgenomic imprinting

Identifiers

PMID34074696
PMCPMC8168557
OpenAlexW3164469050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.