Evidence map›Paper›PMID 34074656›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2021

Elio Adib, Amin H Nassar, Elie W Akl, Sarah Abou Alaiwi, Pier Vitale Nuzzo, Tarek H Mouhieddine, Guru Sonpavde, Robert I Haddad, Kent W Mouw, Marios Giannakis and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 2 pooled it
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 2 syntheses or guidelines pooled it, 126 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Durvalumab Plus Chemotherapy in Patients WithJTO clinical and research reports · 2026
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  13. Loss ofJournal of Cancer · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Interferon Epsilon Loss Is Elusive 9p21 Link to Immune-Cold Tumors, Resistant to Immune Checkpoint Therapy, and Endogenous CXCL9/10 Induction.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2025
    Review
  20. CDKN2A deletion is associated with immune desertification in diffuse pleural mesothelioma.Journal of experimental & clinical cancer research : CR · 2025
    Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Elio Adib *Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Amin H Nassar *Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.ORCID 0000-0002-8084-9105
Elie W Akl *Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Sarah Abou AlaiwiLank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Pier Vitale NuzzoLank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Tarek H MouhieddineDepartment of Internal Medicine, Icahn School of Medicine at Mount Sinai, The Mount Sinai Hospital, New York, New York.ORCID 0000-0002-1190-5978
Guru SonpavdeLank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Robert I HaddadDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Kent W MouwDepartment of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Marios GiannakisDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
F Stephen HodiMelanoma Center, Dana-Farber Cancer Institute, Boston, Massachusetts.
Sachet A ShuklaTranslational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, Massachusetts.ORCID 0000-0003-2445-3584
Alexander GusevDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
David A BraunLank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Toni K ChoueiriLank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
David J KwiatkowskiDepartment of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. dk@rics.bwh.harvard.edu.ORCID 0000-0002-5668-5219
Dana-Farber Cancer Institute · USBrigham and Women's Hospital · USMount Sinai Hospital · US

Funding

Treating the P13-Kinase/AKTP50CA101942 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Wanling Xie · 2003 to 2026
$53.4M
(PQ3) A functional genomic approach to identification and interpretation of germline-tumor genetic interactionsR01CA227237 · NCI · DANA-FARBER CANCER INST · PI GUSEV, ALEXANDER, ZAITLEN, NOAH A · 2018 to 2022
$3.5M
Characterizing non-coding somatic and germline variant interactions in ovarian cancerR01CA244569 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GAYTHER, SIMON ANDREW, GUSEV, ALEXANDER · 2020 to 2024
$3.3M
Immunogenomic analytical approaches for research and clinical applicationsR50CA211482 · NCI · DANA-FARBER CANCER INST · PI SHUKLA, SACHET ASHOK · 2016 to 2020
$1.3M
NCI NIH HHS P50 CA101942NCI NIH HHS R01 CA227237NCI NIH HHS R01 CA244569NCI NIH HHS R50 CA211482
6 · The paper itself

Abstract

purposeImmune checkpoint inhibitors (ICI) have shown clinical benefit in many types of metastatic cancers with only a few predictive biomarkers identified so far. EXPERIMENTAL

designWe studied the association between loss-of-function

resultsIn the DFCI cohort,

conclusionsOur data show that

Indexed as

ImmunotherapyMutationAdultAgedAged, 80 and overCyclin-Dependent Kinase Inhibitor p16HumansImmune Checkpoint InhibitorsMiddle AgedNeoplasmsTreatment OutcomeCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16Immune Checkpoint Inhibitors

Identifiers

PMID34074656
PMCPMC8900067
OpenAlexW3164920857

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.