Evidence map›Paper›PMID 34074326›Full record

ArticleGenome medicine2021

Advancing precision public health using human genomics: examples from the field and future research opportunities.

Megan C Roberts, Alison E Fohner, Latrice Landry, Dana Lee Olstad, Amelia K Smit, Erin Turbitt, Caitlin G Allen

Abstract read
In one paragraph

Article in Genome medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Predictors of genetic risk recall among the participants of a randomized controlled precision prevention trial against melanoma.Genetics in medicine : official journal of the American College of Medical Genetics · 2023
    Trial
  2. Trial
  3. Environmental factors shaping cancer outcomes in Alabama: A scoping review.Journal of cancer survivorship : research and practice · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. The value of large-scale programmes in human genomics.European journal of human genetics : EJHG · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Placing Publics in Public Health Genomics.Public health genomics · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Megan C RobertsDivision of Pharmaceutical Outcomes and Policy, University of North Carolina Eshelman School of Pharmacy, 301 Pharmacy Lane, Chapel Hill, NC, 27599, USA.
Alison E FohnerDepartment of Epidemiology and Institute of Public Health Genetics, University of Washington, 1959 NE Pacific Ave, Seattle, WA, 98195, USA.
Latrice LandryHarvard Medical School, Harvard T.H. Chan School of Public Health, Brigham and Women's Hospital &The Division of Population Sciences in Dana Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215-5450, USA.
Dana Lee OlstadDepartment of Community Health Sciences, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, AB, T2N 4Z6, Canada.
Amelia K SmitCancer Epidemiology and Prevention Research, Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, 119-143 Missenden Road, Camperdown, NSW, 2050, Australia.
Erin TurbittDiscipline of Genetic Counselling, The University of Technology Sydney, 100 Broadway, Ultimo, NSW, 2008, Australia.
Caitlin G AllenDepartment of Behavioral Social and Health Education Sciences, Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA, 30322, USA. calle27@emory.edu.ORCID 0000-0002-6288-3529

Funding

North Carolina Translational and Clinical Science Institute (NC TraCS) KL2KL2TR002490 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WEINBERGER, MORRIS · 2018 to 2022
$11.0M
Improving Family Cancer History Collection using Social Network, Human Centered Design, and Implementation Science ApproachesK00CA253576 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ALLEN, CAITLIN GLOECKNER · 2020 to 2024
$443k
NCATS NIH HHS KL2 TR002490NCI NIH HHS F99 CA253576NCI NIH HHS K00 CA253576
6 · The paper itself

Abstract

Precision public health is a relatively new field that integrates components of precision medicine, such as human genomics research, with public health concepts to help improve population health. Despite interest in advancing precision public health initiatives using human genomics research, current and future opportunities in this emerging field remain largely undescribed. To that end, we provide examples of promising opportunities and current applications of genomics research within precision public health and outline future directions within five major domains of public health: biostatistics, environmental health, epidemiology, health policy and health services, and social and behavioral science. To further extend applications of genomics within precision public health research, three key cross-cutting challenges will need to be addressed: developing policies that implement precision public health initiatives at multiple levels, improving data integration and developing more rigorous methodologies, and incorporating initiatives that address health equity. Realizing the potential to better integrate human genomics within precision public health will require transdisciplinary efforts that leverage the strengths of both precision medicine and public health.

Indexed as

Genome, HumanGenomicsHealth PolicyHumansPrecision MedicinePublic HealthQuality ImprovementQuality of Health CareResearchHuman genomics researchPrecision medicinePrecision public healthPublic healthTransdisciplinary research

Identifiers

PMID34074326
PMCPMC8168000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.