ArticleJournal of orthopaedic surgery and research2021
Treadmill running induces remodeling of the infrapatellar fat pad in an intensity-dependent manner.
Article in Journal of orthopaedic surgery and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 4 citations in OpenAlex.
- Treadmill running modulates infrapatellar fat pad remodeling in osteoarthritic rats in an intensity-dependent manner.BMC sports science, medicine & rehabilitation · 2026Article
- Exercise intensity-dependent metabolic adaptations in streptozotocin-induced diabetic rats: modulatory effects of apple cider vinegar on inflammatory and endocrine biomarkers.Frontiers in physiology · 2026Article
- Exercise and Carnosine Modulate Microbiota-Derived Metabolites, Myokines, and Cardiometabolic Profiles in Rats: A Randomized Controlled Trial.Biomedicines · 2025Article
- Mechanosensitive lncRNA H19 promotes chondrocyte autophagy, but not pyroptosis, by targeting miR-148a in post-traumatic osteoarthritis.Non-coding RNA research · 2025Article
- A high throughput cell stretch device for investigating mechanobiologyAPL bioengineering · 2024Article
- Exercise promotes osteogenic differentiation by activating the long non-coding RNA H19/microRNA-149 axis.World journal of orthopedics · 2024Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo investigate the response of the infrapatellar fat pad (IFP) to running at different intensities and further explore the underlying mechanisms of these responses under different running-induced loadings.
methodsAnimals were randomly assigned into the sedentary (SED), low-intensity running (LIR), medium-intensity running (MIR), and high-intensity running (HIR) groups. The rats in the LIR, MIR, and HIR groups were subjected to an 8-week treadmill running protocol. In each group, the IFP was examined at the baseline and at the 8th week to perform histomorphology, immunohistochemistry, and mRNA expression analyses.
resultsCompared with LIR and MIR, HIR for 8 weeks led to a substantial increase in the surface cellularity (1.67 ± 1.15), fibrosis (1.29 ± 0.36), and vascularity (33.31 ± 8.43) of the IFP but did not increase IFP inflammation or M1 macrophage polarization. Low-to-medium-intensity running resulted in unchanged or decreased fibrosis, vascularity, and surface cellularity in the IFP compared to those of the SED group. Furthermore, serum leptin and visfatin levels were significantly lower in the LIR and MIR groups than in the SED group or the HIR group (P < 0.05).
conclusionThe effect of running on IFP remodeling was intensity dependent. In contrast to LIR and MIR, HIR increased the fibrosis and vascularity of the IFP. HIR-induced IFP fibrosis was probably due to mechanical stress, rather than pathological proinflammatory M1/M2 polarization.
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