Evidence map›Paper›PMID 34074291›Full record

Trial reportJournal of orthopaedic surgery and research2021

Percutaneous periarticular analgesic injection at one day after simultaneous bilateral total knee arthroplasty: an open-label randomized control trial.

Takuya Iseki, Sachiyuki Tsukada, Motohiro Wakui, Kenji Kurosaka, Shinichi Yoshiya, Toshiya Tachibana

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of orthopaedic surgery and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Takuya IsekiDepartment of Orthopaedic Surgery, Nekoyama Miyao Hospital, 14-7 Konan, Chuo-ku, 950-1151, Niigata, Japan. takuyaiseki@gmail.com.ORCID http://orcid.org/0000-0001-6729-8946
Sachiyuki TsukadaDepartment of Orthopaedic Surgery, Nekoyama Miyao Hospital, 14-7 Konan, Chuo-ku, 950-1151, Niigata, Japan.
Motohiro WakuiDepartment of Orthopaedic Surgery, Nekoyama Miyao Hospital, 14-7 Konan, Chuo-ku, 950-1151, Niigata, Japan.
Kenji KurosakaDepartment of Orthopaedic Surgery, Houksuikai Kinen Hospital, 3-2-1 Higashihara, Mito, 310-0035, Ibaraki, Japan.
Shinichi YoshiyaDepartment of Orthopaedic Surgery, Nishinomiya Kaisei Hospital, 1-4 Ohama-cho, Nishinomiya, 662-0957, Hyogo, Japan.
Toshiya TachibanaDepartment of Orthopaedic Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe postoperative pain after total knee arthroplasty (TKA) remains a critical issue. The aim of this study was to assess the clinical effectiveness of percutaneous periarticular injection at 1 day following simultaneous bilateral TKA.

methodsA total of 88 knees in 44 patients who underwent simultaneous bilateral TKA were randomly assigned to receive a percutaneous periarticular injection at 1 day following surgery (n = 22 patients) or no injection (n = 22 patients). In the additional injection group, we injected a solution including methylprednisolone, ropivacaine, and epinephrine into the muscle belly of the vastus medialis at 1 day after surgery. In both groups, patients received an intraoperative periarticular multi-drug injection and postoperative intravenous and oral nonsteroidal anti-inflammatory drugs. The primary outcome measure was the postoperative pain at rest using a visual analog scale (VAS) and analyzed with Student's t test.

resultsCompared to the no additional injection group, the additional periarticular injection group had significantly lower VAS score at 8:00 PM postoperative day 1, 6:00 AM postoperative day 2, 12:00 PM postoperative day 2, 6:00 AM postoperative day 5, 12:00 PM postoperative day 5, and 8:00 PM postoperative day 5 (p < 0.05). The rate of complication did not differ between groups (p > 0.05).

conclusionAdditional percutaneous periarticular injection at 1 day following TKA adding to intraoperative periarticular injection provided better postoperative pain relief.

trial registrationRegistered at the University Hospital Medical Information Network (registration number: UMIN000029759 ).

Indexed as

AgedAged, 80 and overAnalgesicsArthroplasty, Replacement, KneeDrug Therapy, CombinationEpinephrineFemaleHumansInjections, Intra-ArticularInjections, IntralesionalInjections, IntramuscularMaleMethylprednisolonePain ManagementPostoperative PainRopivacaineAnalgesicsEpinephrineMethylprednisoloneRopivacaineAdditional injectionPostoperative painRandomizedSimultaneous bilateral total knee arthroplasty

Identifiers

PMID34074291
PMCPMC8170951

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.