Evidence map›Paper›PMID 34074170›Full record

ArticleJournal of human lactation : official journal of International Lactation Consultant Association2022

Changes in Antisecretory Factor in Human Milk During the Postpartum and Length of Gestation.

Anna Gustafsson, Ewa Johansson, Ewa Henckel, Stefan Lange, Kajsa Bohlin

Open access · hybridAbstract read
In one paragraph

Article in Journal of human lactation : official journal of International Lactation Consultant Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Anna Gustafsson27106 Department of Neonatology, Karolinska University Hospital, Stockholm, Sweden.
Ewa Johansson99018 Department of Infectious Diseases, Institute of Biomedicine, Gothenburg University, Gothenburg, Sweden.
Ewa Henckel27106 Department of Neonatology, Karolinska University Hospital, Stockholm, Sweden.
Stefan Lange99018 Department of Infectious Diseases, Institute of Biomedicine, Gothenburg University, Gothenburg, Sweden.
Kajsa Bohlin27106 Department of Neonatology, Karolinska University Hospital, Stockholm, Sweden.
Karolinska University Hospital · SEKarolinska Institutet · SERegion Västra Götaland · SEUniversity of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreterm infants are more susceptible to inflammatory complications than term infants. Human milk contains numerous bioactive components protecting the newborn infant. Antisecretory factor, a protein regulating secretory and inflammatory processes by complex binding with complement factors, is present in human milk. RESEARCH

aimsTo describe antisecretory factor (1) in mother's own milk in term and preterm infants; and (2) in donor milk before and after Holder pasteurization.

methodsThe study was prospective, longitudinal, explorative, and descriptive. Antisecretory factor-compleasome was determined using sandwich enzyme-linked immunosorbent assay in longitudinal human milk samples over 12 weeks from mothers (

resultsAntisecretory factor-compleasome was overall higher in colostrum versus mature milk (

conclusionAntisecretory factor followed the pattern of other immunological factors with high levels in colostrum. After preterm birth, levels of antisecretory factor were higher and more variable in mature milk. Holder pasteurization did not degrade antisecretory factor, indicating preserved anti-inflammatory properties in donor human milk.

Indexed as

Milk, HumanPremature BirthBreast FeedingFemaleHumansInfantInfant, NewbornInfant, PrematureNeuropeptidesPasteurizationPostpartum PeriodProspective Studiesantisecretory factorNeuropeptidesAntisecretory Factorbreastfeedingcolostrumhuman milklactationmilk bankmilk compositionneonatologyprematurity

Identifiers

PMID34074170
PMCPMC8814942
OpenAlexW3164469556

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.