Evidence map›Paper›PMID 34074015›Full record

ArticleInternational journal of molecular sciences2021

Mutant p53 Mediates Sensitivity to Cancer Treatment Agents in Oesophageal Adenocarcinoma Associated with MicroRNA and SLC7A11 Expression.

Ann-Kathrin Eichelmann, George C Mayne, Karen Chiam, Steven L Due, Isabell Bastian, Frederike Butz, Tingting Wang, Pamela J Sykes, Nicholas J Clemons, David S Liu and 5 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
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  6. Review
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  9. Article
  10. miRNA profiling of esophageal adenocarcinoma using transcriptome analysis.Cancer biomarkers : section A of Disease markers · 2024
    Article
  11. Role of ferroptosis in esophageal cancer and corresponding immunotherapy.World journal of gastrointestinal oncology · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Ann-Kathrin EichelmannFlinders Health and Medical Research Institute-Cancer Program, Flinders University, Bedford Park, Adelaide, SA 5042, Australia.ORCID 0000-0002-9037-7009
George C MayneFlinders Health and Medical Research Institute-Cancer Program, Flinders University, Bedford Park, Adelaide, SA 5042, Australia.
Karen ChiamFlinders Health and Medical Research Institute-Cancer Program, Flinders University, Bedford Park, Adelaide, SA 5042, Australia.ORCID 0000-0001-8154-6731
Steven L DueFlinders Health and Medical Research Institute-Cancer Program, Flinders University, Bedford Park, Adelaide, SA 5042, Australia.
Isabell BastianFlinders Health and Medical Research Institute-Cancer Program, Flinders University, Bedford Park, Adelaide, SA 5042, Australia.
Frederike ButzFlinders Health and Medical Research Institute-Cancer Program, Flinders University, Bedford Park, Adelaide, SA 5042, Australia.
Tingting WangFlinders Health and Medical Research Institute-Cancer Program, Flinders University, Bedford Park, Adelaide, SA 5042, Australia.ORCID 0000-0002-7739-4787
Pamela J SykesFlinders Health and Medical Research Institute-Cancer Program, Flinders University, Bedford Park, Adelaide, SA 5042, Australia.
Nicholas J ClemonsPeter MacCallum Cancer Centre, 305 Grattan St, Melbourne, VIC 3000, Australia.ORCID 0000-0001-9283-9978
David S LiuPeter MacCallum Cancer Centre, 305 Grattan St, Melbourne, VIC 3000, Australia.
Michael Z MichaelFlinders Health and Medical Research Institute-Cancer Program, Flinders University, Bedford Park, Adelaide, SA 5042, Australia.
Christos S KarapetisFlinders Health and Medical Research Institute-Cancer Program, Flinders University, Bedford Park, Adelaide, SA 5042, Australia.
Richard HummelDepartment of Surgery, University Hospital of Schleswig-Holstein, Ratzeburger Allee 160, 23538 Lübeck, Germany.
David I WatsonFlinders Health and Medical Research Institute-Cancer Program, Flinders University, Bedford Park, Adelaide, SA 5042, Australia.ORCID 0000-0002-7683-2693
Damian J HusseyFlinders Health and Medical Research Institute-Cancer Program, Flinders University, Bedford Park, Adelaide, SA 5042, Australia.ORCID 0000-0002-6121-6740
Flinders University · AUPeter MacCallum Cancer Centre · AUThe University of Melbourne · AUUniversity Hospital Schleswig-Holstein · DE

Funding

FCIC Cancer Research Grant (funded by Flinders Foundation): Identification of MicroRNA-Messenger RNA regulatory modules that determine biological responses to chemoradiotherapy in Oesophageal Adenocarcinoma. N.A.Flinders University MNHS Grants System: Tumoural Small Non-Coding RNAs and Radiation Response in Oesophageal Adenocarcinoma N.A.
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdenocarcinomaAmino Acid Transport System y+Antineoplastic AgentsApoptosisCell Line, TumorCell SurvivalCisplatinDrug Resistance, NeoplasmEsophageal NeoplasmsEstrogensGene Expression Regulation, NeoplasticGene Knockout TechniquesGene OntologyGlutathioneHumansMicroRNAsAmino Acid Transport System y+Antineoplastic AgentsCisplatinEstrogensGlutathioneMicroRNAsSLC7A11 protein, humanTP53 protein, humanTumor Suppressor Protein p53chemoresistancemiR-27a-3pmiRNAoesophageal canceroestrogen receptor modulatorradioresistancereactive oxidative speciesribosomeSLC7A11xCT

Identifiers

PMID34074015
PMCPMC8197322
OpenAlexW3164016672

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.