Evidence map›Paper›PMID 34073962›Full record

ReviewMolecules (Basel, Switzerland)2021

Pharmacological Insights into Halophyte Bioactive Extract Action on Anti-Inflammatory, Pain Relief and Antibiotics-Type Mechanisms.

Rocco Giordano, Zeinab Saii, Malthe Fredsgaard, Laura Sini Sofia Hulkko, Thomas Bouet Guldbæk Poulsen, Mikkel Eggert Thomsen, Nanna Henneberg, Silvana Maria Zucolotto, Lars Arendt-Nielsen, Jutta Papenbrock and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 64 citations in OpenAlex.

  1. Review
  2. Bioactive Compounds of Aboveground OrgansMolecules (Basel, Switzerland) · 2026
    Article
  3. Food and waterborne parasitology · 2026
    Article
  4. Development and Characterization ofLife (Basel, Switzerland) · 2026
    Article
  5. Review
  6. Article
  7. Review
  8. ValorizingInternational journal of food science · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. DietaryFrontiers in immunology · 2024
    Article
  14. Exploring the Antioxidant and Genoprotective Potential ofAnimals : an open access journal from MDPI · 2023
    Article
  15. Inhibitory Effects of Sesquiterpenoids Isolated fromInternational journal of molecular sciences · 2023
    Article
  16. Water Extract of DesaltedNutrients · 2023
    Article
  17. Phenolic Compounds inMolecules (Basel, Switzerland) · 2023
    Review
  18. Harnessing the Value ofMarine drugs · 2023
    Article
  19. Article
  20. Sea Fennel (Molecules (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Rocco GiordanoDepartment of Health Science and Technology, Aalborg University, 9220 Aalborg, Denmark.ORCID 0000-0003-1331-129X
Zeinab SaiiDepartment of Health Science and Technology, Aalborg University, 9220 Aalborg, Denmark.ORCID 0000-0003-4111-2714
Malthe FredsgaardDepartment of Energy Technology, Aalborg University, 9220 Aalborg, Denmark.
Laura Sini Sofia HulkkoDepartment of Energy Technology, Aalborg University, 9220 Aalborg, Denmark.
Thomas Bouet Guldbæk PoulsenDepartment of Health Science and Technology, Aalborg University, 9220 Aalborg, Denmark.ORCID 0000-0003-2577-5868
Mikkel Eggert ThomsenDepartment of Health Science and Technology, Aalborg University, 9220 Aalborg, Denmark.
Nanna HennebergDepartment of Health Science and Technology, Aalborg University, 9220 Aalborg, Denmark.ORCID 0000-0001-9408-2833
Silvana Maria ZucolottoCenter of Health Sciences, Department of Pharmaceutical Science, Federal University of Santa Catarina, Campus Universitário, Trindade, 88040-970 Florianópolis, Brazil.ORCID 0000-0002-2768-0793
Lars Arendt-NielsenDepartment of Health Science and Technology, Aalborg University, 9220 Aalborg, Denmark.ORCID 0000-0003-0892-1579
Jutta PapenbrockInstitute of Botany, Leibniz University Hannover, D-30419 Hannover, Germany.ORCID 0000-0003-0942-4072
Mette Hedegaard ThomsenDepartment of Energy Technology, Aalborg University, 9220 Aalborg, Denmark.
Allan StensballeDepartment of Health Science and Technology, Aalborg University, 9220 Aalborg, Denmark.ORCID 0000-0002-9888-1955
Aalborg University · DKLeibniz University Hannover · DEUniversidade Federal de Santa Catarina · BR

Funding

Horizon 2020 Framework Programme 862834
6 · The paper itself

Abstract

The pharmacological activities in bioactive plant extracts play an increasing role in sustainable resources for valorization and biomedical applications. Bioactive phytochemicals, including natural compounds, secondary metabolites and their derivatives, have attracted significant attention for use in both medicinal products and cosmetic products. Our review highlights the pharmacological mode-of-action and current biomedical applications of key bioactive compounds applied as anti-inflammatory, bactericidal with antibiotics effects, and pain relief purposes in controlled clinical studies or preclinical studies. In this systematic review, the availability of bioactive compounds from several salt-tolerant plant species, mainly focusing on the three promising species

Indexed as

AnalgesicsAnti-Bacterial AgentsAnti-Inflammatory AgentsHumansPlant ExtractsSalt-Tolerant PlantsAnalgesicsAnti-Bacterial AgentsAnti-Inflammatory AgentsPlant Extractshalophyteshydroxycinnamic acidinflammationnutraceuticalssecondary metabolites

Identifiers

PMID34073962
PMCPMC8197292
OpenAlexW3164291452

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.