ArticleDiagnostics (Basel, Switzerland)2021
Vitamin D and Folate as Predictors of MMSE in Alzheimer's Disease: A Machine Learning Analysis.
Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Prediction of Verbal Abilities From Brain Connectivity Data Across the Lifespan Using a Machine Learning Approach.Human brain mapping · 2025Article
- Diagnosis of Alzheimer's disease using transfer learning with multi-modal 3D Inception-v4.Quantitative imaging in medicine and surgery · 2025Article
- Establishment and validation of HPLC methods for the determination of folic acid and parabens antimicrobial agents on folic acid oral solution.BMC chemistry · 2025Article
- Say hello to my little friend… micronutraceuticals in neuroenergetics, neuronal health, and neurodegenerative diseases.Frontiers in neuroscience · 2025Review
- Enhanced ROS Production and Mitochondrial Metabolic Shifts in CD4International journal of molecular sciences · 2024Article
- Vitamin D: An Essential Nutrient in the Dual Relationship between Autoimmune Thyroid Diseases and Celiac Disease-A Comprehensive Review.Nutrients · 2024Review
- Explainable AI and transformer models: Unraveling the nutritional influences on Alzheimer's disease mortality.Smart health (Amsterdam, Netherlands) · 2024Article
- Intelligent prediction of Alzheimer's disease via improved multifeature squeeze-and-excitation-dilated residual network.Scientific reports · 2024Article
- Differential predictability of cognitive profiles from brain structure in older males and females.GeroScience · 2024Article
- Supervised Parametric Learning in the Identification of Composite Biomarker Signatures of Type 1 Diabetes in Integrated Parallel Multi-Omics Datasets.Biomedicines · 2024Article
- Prediction of cognitive performance differences in older age from multimodal neuroimaging data.GeroScience · 2024Article
- The Role of Micronutrients in Neurological Disorders.Nutrients · 2023Review
- Perspectives on Neuronutrition in Prevention and Treatment of Neurological Disorders.Nutrients · 2023Review
- Biomarkers of Micronutrients and Phytonutrients and Their Application in Epidemiological Studies.Nutrients · 2023Review
- Role of micronutrients in Alzheimer's disease: Review of available evidence.World journal of clinical cases · 2022Review
- Review
- A novel deep learning approach for diagnosing Alzheimer's disease based on eye-tracking data.Frontiers in human neuroscience · 2022Article
- A Machine Learning Application to Predict Early Lung Involvement in Scleroderma: A Feasibility Evaluation.Diagnostics (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D (VD) and micronutrients, including folic acid, are able to modulate both the innate and the adaptive immune responses. Low VD and folic acid levels appear to promote cognitive decline as in Alzheimer's disease (AD). A machine learning approach was applied to analyze the impact of various compounds, drawn from the blood of AD patients, including VD and folic acid levels, on the Mini-Mental State Exam (MMSE) in a cohort of 108 patients with AD. The first analysis was aimed at predicting the MMSE at recruitment, whereas a second investigation sought to predict the MMSE after a 4 year follow-up. The simultaneous presence of low levels of VD and folic acid allow to predict MMSE, suggestive of poorer cognitive function. Such results suggest that the low levels of VD and folic acid could be associated with more severe cases of cognitive impairment in AD. It could be hypothesized that simultaneous supplementation of VD and folic acid could slow down the progression of cerebral degeneration at least in a subset of AD individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.