Evidence map›Paper›PMID 34073722›Full record

ArticleCancers2021

A Circulating Exosome RNA Signature Is a Potential Diagnostic Marker for Pancreatic Cancer, a Systematic Study.

Yixing Wu, Hongmei Zeng, Qing Yu, Huatian Huang, Beatrice Fervers, Zhe-Sheng Chen, Lingeng Lu

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Small extracellular vesicles (sEVs) in pancreatic cancer progression and diagnosis.Journal of controlled release : official journal of the Controlled Release Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

Yixing WuDepartment of Endocrinology, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China.
Hongmei ZengNational Central Cancer Registry, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Qing YuCenter for Cancer and Blood Disorders, Children's National Medical Center, Washington, DC 20010, USA.
Huatian HuangDepartment of Imaging, Guizhou Qianxinan People's Hospital, Xingyi 652400, China.
Beatrice FerversDépartement Prévention Cancer Environnement, Centre Léon Bérard-Université Lyon 1, 69008 Lyon, France.
Zhe-Sheng ChenDepartment of Pharmaceutical Sciences, St. John's University, New York, NY 11439, USA.ORCID 0000-0002-8289-097X
Lingeng LuDepartment of Chronic Disease Epidemiology, Yale School of Public Health, School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0001-9871-0809
Children's National · USChinese Academy of Medical Sciences & Peking Union Medical College · CNSecond Affiliated Hospital of Guangzhou Medical University · CNSt. John's University · USUniversité Claude Bernard Lyon 1 · FRYale Cancer Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Several exosome proteins, miRNAs and

Indexed as

early detectionexosomeKRAS mutationpancreatic cancerRNA signature

Identifiers

PMID34073722
PMCPMC8197236
OpenAlexW3164251924

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.