Evidence map›Paper›PMID 34073640›Full record

ArticleJournal of clinical medicine2021

Characterization of the GHB Withdrawal Syndrome.

Casper J H Wolf, Harmen Beurmanjer, Boukje A G Dijkstra, Alexander C Geerlings, Marcia Spoelder, Judith R Homberg, Arnt F A Schellekens

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Casper J H WolfMedical Center, Department of Psychiatry, Radboud University, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-8886-3745
Harmen BeurmanjerNijmegen Institute for Scientist-Practitioners in Addiction (NISPA), 6525 HR Nijmegen, The Netherlands.ORCID 0000-0003-1864-1589
Boukje A G DijkstraNijmegen Institute for Scientist-Practitioners in Addiction (NISPA), 6525 HR Nijmegen, The Netherlands.ORCID 0000-0003-1467-7808
Alexander C GeerlingsMedical Center, Department of Psychiatry, Radboud University, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-9146-8164
Marcia SpoelderDepartment of Cognitive Neuroscience, Donders Institute for Brain Cognition and Behaviour, Radboud University, 6525 EN, Nijmegen, The Netherlands.ORCID 0000-0002-9217-0642
Judith R HombergDepartment of Cognitive Neuroscience, Donders Institute for Brain Cognition and Behaviour, Radboud University, 6525 EN, Nijmegen, The Netherlands.ORCID 0000-0002-7621-1010
Arnt F A SchellekensMedical Center, Department of Psychiatry, Radboud University, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-7715-5209
Radboud University Nijmegen · NLNijmegen Institute for Scientist Practitioners in Addiction · NL

Funding

Ministerie van Volksgezondheid, Welzijn en Sport 316997
6 · The paper itself

Abstract

The gamma-hydroxybutyric acid (GHB) withdrawal syndrome can have a fulminant course, complicated by severe complications such as delirium or seizures. Detoxification by tapering with pharmaceutical GHB is a safe way to manage GHB withdrawal. However, a detailed description of the course of the GHB withdrawal syndrome is currently lacking. This study aimed to (1) describe the course of GHB withdrawal symptoms over time, (2) assess the association between vital signs and withdrawal symptoms, and (3) explore sex differences in GHB withdrawal. In this observational multicenter study, patients with GHB use disorder (

Indexed as

abstinenceaddictiondependencedetoxificationgamma-hydroxybutyric acidGHBsex differencestreatmentwithdrawal

Identifiers

PMID34073640
PMCPMC8199158
OpenAlexW3164037498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.