ArticleBiomedicines2021
Occlusion of the Superior Mesenteric Artery in Rats Reversed by Collateral Pathways Activation: Gastric Pentadecapeptide BPC 157 Therapy Counteracts Multiple Organ Dysfunction Syndrome; Intracranial, Portal, and Caval Hypertension; and Aortal Hypotension.
Open access · goldAbstract read
In one paragraph
Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 27 citations in OpenAlex.
- Unilateral Adrenalectomy, and the Stable Pentadecapeptide BPC 157 as Therapy in Rats-A Cytoprotection Approach.Pharmaceuticals (Basel, Switzerland) · 2026Article
- BPC-157 as an Investigational Peptide Therapeutic: Biopharmaceutical Challenges, Formulation Strategies, and Translational Development Barriers.Pharmaceutics · 2026Review
- Cytoprotection as a Unifying Strategy for Hemorrhage and Thrombosis: The Role of BPC 157 and Related Therapeutics.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Conventional Antiarrhythmics Class I-IV, Late INa Inhibitors, IKs Enhancers, RyR2 Stabilizers, Gap Junction Modulators, Atrial-Selective Antiarrhythmics, and Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Therapy in Arrhythmias.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Challenge of Corneal Ulcer Healing: A Novel Conceptual Framework, the "Triad" of Corneal Ulcer Healing/Corneal Neovascularization/Intraocular Pressure, and Avascular Tendon Healing, for Evaluation of Corneal Ulcer Therapy, Therapy of Neovascularization, Glaucoma Therapy, and Pentadecapeptide BPC 157 Efficacy.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Stable Gastric Pentadecapeptide BPC 157 as a Therapy and Safety Key: A Special Beneficial Pleiotropic Effect Controlling and Modulating Angiogenesis and the NO-System.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Acute Compartment Syndrome and Intra-Abdominal Hypertension, Decompression, Current Pharmacotherapy, and Stable Gastric Pentadecapeptide BPC 157 Solution.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Protective Effects of BPC 157 on Liver, Kidney, and Lung Distant Organ Damage in Rats with Experimental Lower-Extremity Ischemia-Reperfusion Injury.Medicina (Kaunas, Lithuania) · 2025Article
- New studies with stable gastric pentadecapeptide protecting gastrointestinal tract. significance of counteraction of vascular and multiorgan failure of occlusion/occlusion-like syndrome in cytoprotection/organoprotection.Inflammopharmacology · 2024Review
- Stable Gastric Pentadecapeptide BPC 157 and Intestinal Anastomoses Therapy in Rats-A Review.Pharmaceuticals (Basel, Switzerland) · 2024Review
- The Stable Gastric Pentadecapeptide BPC 157 Pleiotropic Beneficial Activity and Its Possible Relations with Neurotransmitter Activity.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Stable Gastric Pentadecapeptide BPC 157 Therapy: Effect on Reperfusion Following Maintained Intra-Abdominal Hypertension (Grade III and IV) in Rats.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Pentadecapeptide BPC 157 as Therapy for Inferior Caval Vein Embolization: Recovery of Sodium Laurate-Post-Embolization Syndrome in Rats.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Stable Gastric Pentadecapeptide BPC 157-Possible Novel Therapy of Glaucoma and Other Ocular Conditions.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Stomach perforation-induced general occlusion/occlusion-like syndrome and stable gastric pentadecapeptide BPC 157 therapy effect.World journal of gastroenterology · 2023Article
- Antiarrhythmic Sotalol, Occlusion/Occlusion-like Syndrome in Rats, and Stable Gastric Pentadecapeptide BPC 157 Therapy.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Innate Vascular Failure by Application of Neuroleptics, Amphetamine, and Domperidone Rapidly Induced Severe Occlusion/Occlusion-like Syndromes in Rats and Stable Gastric Pentadecapeptide BPC 157 as Therapy.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Stable Gastric Pentadecapeptide BPC 157 May Recover Brain-Gut Axis and Gut-Brain Axis Function.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Fourier Transform Infrared Spectroscopy Reveals Molecular Changes in Blood Vessels of Rats Treated with Pentadecapeptide BPC 157.Biomedicines · 2022Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 2 institutions in 1 country.
Mario KnezevicDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Slaven GojkovicDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Ivan KrezicDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Helena ZizekDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Dominik MalekinusicDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Borna VrdoljakDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.ORCID 0000-0003-2306-8799
Hrvoje VranesDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Tamara KnezevicDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Ivan BarisicDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Katarina Horvat PavlovDepartment of Pathology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Domagoj DrmicDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Miro StaroveskiDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Antonija DjuzelDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Zoran RajkovicDepartment of Surgery, Faculty of Dental Medicine and Health, University of Osijek, 31000 Osijek, Croatia.
Toni KolakDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Ivica KocmanDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Eva LovricDepartment of Pathology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Marija MilavicDepartment of Pathology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Suncana SikiricDepartment of Pathology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Ante TvrdeicDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Leonardo PatrljDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Sanja StrbeDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Antonio KokotDepartment of Anatomy and Neuroscience, School of Medicine, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia.
Alenka Boban BlagaicDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Anita SkrticDepartment of Pathology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.ORCID 0000-0002-9275-7283
Sven SeiwerthDepartment of Pathology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Predrag SikiricDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
University of Zagreb · HRUniversity of Osijek · HR
Funding
Sveučilište u Zagrebu 099
Abstract
Gastric pentadecapeptide BPC 157 therapy counteracts multiple organ dysfunction syndrome in rats, which have permanent occlusion of the superior mesenteric artery close to the abdominal aorta. Previously, when confronted with major vessel occlusion, its effect would rapidly activate collateral vessel pathways and resolve major venous occlusion syndromes (Pringle maneuver ischemia, reperfusion, Budd-Chiari syndrome) in rats. This would overwhelm superior mesenteric artery permanent occlusion, and result in local, peripheral, and central disturbances.
Indexed as
BPC 157ratssuperior mesenteric artery occlusionvascular recruitment
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.