Evidence map›Paper›PMID 34073591›Full record

ArticleBiomolecules2021

Lower Gene Expression of Angiotensin Converting Enzyme 2 Receptor in Lung Tissues of Smokers with COVID-19 Pneumonia.

Francesca Lunardi, Francesco Fortarezza, Luca Vedovelli, Federica Pezzuto, Annalisa Boscolo, Marco Rossato, Roberto Vettor, Anna Maria Cattelan, Claudia Del Vecchio, Andrea Crisanti and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Francesca LunardiDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova Medical School, 35128 Padova, Italy.
Francesco FortarezzaDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova Medical School, 35128 Padova, Italy.ORCID 0000-0002-8954-5888
Luca VedovelliDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova Medical School, 35128 Padova, Italy.ORCID 0000-0003-4847-2333
Federica PezzutoDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova Medical School, 35128 Padova, Italy.ORCID 0000-0002-8023-3108
Annalisa BoscoloDepartment of Medicine, University of Padova Medical School, 35128 Padova, Italy.
Marco RossatoDepartment of Medicine, University of Padova Medical School, 35128 Padova, Italy.ORCID 0000-0003-4327-2500
Roberto VettorDepartment of Medicine, University of Padova Medical School, 35128 Padova, Italy.
Anna Maria CattelanDepartment of Medicine, University of Padova Medical School, 35128 Padova, Italy.ORCID 0000-0003-2869-2945
Claudia Del VecchioDepartment of Molecular Medicine, University of Padova Medical School, 35121 Padova, Italy.
Andrea CrisantiDepartment of Molecular Medicine, University of Padova Medical School, 35121 Padova, Italy.
Paolo NavalesiDepartment of Medicine, University of Padova Medical School, 35128 Padova, Italy.ORCID 0000-0002-3733-3453
Dario GregoriDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova Medical School, 35128 Padova, Italy.ORCID 0000-0001-7906-0580
Fiorella CalabreseDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova Medical School, 35128 Padova, Italy.
University of Padua · IT

Funding

University of Padova/Intesa San Paolo Vita bank 2020A08
6 · The paper itself

Abstract

Angiotensin-converting enzyme 2 (ACE-2) is the main cell entry receptor for severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2), thus playing a critical role in causing Coronavirus disease 2019 (COVID-19). The role of smoking habit in the susceptibility to infection is still controversial. In this study we correlated lung ACE-2 gene expression with several clinical/pathological data to explore susceptibility to infection. This is a retrospective observational study on 29 consecutive COVID-19 autopsies. SARS-CoV-2 genome and ACE-2 mRNA expression were evaluated by real-time polymerase chain reaction in lung tissue samples and correlated with several data with focus on smoking habit. Smoking was less frequent in high than low ACE-2 expressors (

Indexed as

AgedAged, 80 and overAngiotensin-Converting Enzyme 2Bayes TheoremCOVID-19FemaleHumansLungMaleReal-Time Polymerase Chain ReactionRetrospective StudiesRisk FactorsSARS-CoV-2SmokersAngiotensin-Converting Enzyme 2angiotensin converting enzyme receptorCOVID-19SARS-CoV-2smoking

Identifiers

PMID34073591
PMCPMC8226817
OpenAlexW3164274236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.