Evidence map›Paper›PMID 34073584›Full record

ArticleMolecules (Basel, Switzerland)2021

PPARα Agonist, MHY3200, Alleviates Renal Inflammation during Aging via Regulating ROS/Akt/FoxO1 Signaling.

Min Jo Kim, Dae Hyun Kim, EunJin Bang, Sang Gyun Noh, Pusoon Chun, Takako Yokozawa, Hyung Ryong Moon, Hae Young Chung

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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  8. Polysaccharide from aerial part ofFrontiers in immunology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Min Jo KimDepartment of Pharmacy, College of Pharmacy, Pusan National University, Geumjeong-gu, Busan 46241, Korea.ORCID 0000-0003-2049-9411
Dae Hyun KimDepartment of Pharmacy, College of Pharmacy, Pusan National University, Geumjeong-gu, Busan 46241, Korea.
EunJin BangDepartment of Pharmacy, College of Pharmacy, Pusan National University, Geumjeong-gu, Busan 46241, Korea.
Sang Gyun NohInterdisciplinary Research Programme of Bioinformatics and Longevity Science, Department of Pharmacy, College of Pharmacy, Pusan National University, Geumjeong-gu, Busan 46241, Korea.
Pusoon ChunCollege of Pharmacy, Inje University, Gimhae 50834, Gyeongsangnam-do, Korea.
Takako YokozawaGraduate School Science and Engineering for Research, University of Toyama, Toyama 930-8555, Japan.
Hyung Ryong MoonDepartment of Pharmacy, College of Pharmacy, Pusan National University, Geumjeong-gu, Busan 46241, Korea.ORCID 0000-0003-1119-7112
Hae Young ChungDepartment of Pharmacy, College of Pharmacy, Pusan National University, Geumjeong-gu, Busan 46241, Korea.ORCID 0000-0002-3215-8828
Pusan National University · KRInje University · KRUniversity of Toyama · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PPARα is a ligand-dependent transcription factor and its activation is known to play an important role in cell defense through anti-inflammatory and antioxidant effects. MHY3200 (2-[4-(5-chlorobenzo[

Indexed as

AcetatesAgingAnimalsBody WeightForkhead Box Protein O1Gene Expression RegulationHypoglycemic AgentsInflammationInsulinKidneyMaleNerve Tissue ProteinsPhosphorylationPPAR alphaProtein BindingProto-Oncogene Proteins c-aktAcetatesAkt1 protein, ratForkhead Box Protein O1Foxo1 protein, ratHypoglycemic AgentsInsulinMHY3200Nerve Tissue ProteinsPPAR alphaProto-Oncogene Proteins c-aktReactive Oxygen SpeciesThiazolesTriglyceridesagingAktinflammationMHY3200NF-κBROS

Identifiers

PMID34073584
PMCPMC8198004
OpenAlexW3164127343

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.