ArticleLife (Basel, Switzerland)2021
Impact of TSPO Receptor Polymorphism on [
Abstract read
In one paragraph
Article in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Evaluating the Clinical Utility of TSPO-PET in MS and the Influence of Methodological Heterogeneity: A Systematic Review and Meta-Analysis.Neurology(R) neuroimmunology & neuroinflammation · 2026Pooled it
- Association between FDG- and TSPO-PET signals across human and animal studies investigating neurodegenerative conditions: a systematic review.Molecular psychiatry · 2026Pooled it
- The prognostic significance of TSPO-PET imaging in IDH-mutant glioma: a single-center, retrospective study.European journal of nuclear medicine and molecular imaging · 2026Article
- Longitudinal [European journal of nuclear medicine and molecular imaging · 2026Article
- Comparing and combining TSPO-PET tracers in tauopathies.European journal of nuclear medicine and molecular imaging · 2026Article
- From clinical phenotypes to molecular precision: multimodal biomarkers for progressive supranuclear palsy.Frontiers in neuroscience · 2026Review
- Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer's disease.Molecular neurodegeneration · 2024Article
- Microvascular Obstruction and Intramyocardial Hemorrhage in Reperfused Myocardial Infarctions: Pathophysiology and Clinical Insights From Imaging.JACC. Cardiovascular imaging · 2024Review
- The development status of PET radiotracers for evaluating neuroinflammation.Nuclear medicine and molecular imaging · 2024Review
- Associations between sex, body mass index and the individual microglial response in Alzheimer's disease.Journal of neuroinflammation · 2024Article
- Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies.Molecular psychiatry · 2023Article
- Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases.Nature communications · 2023Article
- Clinical Applications of TSPO PET for Glioma Imaging: Current Evidence and Future Perspective-A Systematic Review.Diagnostics (Basel, Switzerland) · 2023Review
- Translocator protein in the rise and fall of central nervous system neurons.Frontiers in cellular neuroscience · 2023Review
- Tracers progress for positron emission tomography imaging of glial-related disease.Journal of biomedical research · 2022Article
- Review
- Impact of Partial Volume Correction on [Brain sciences · 2022Article
- Novel brain PET imaging agents: Strategies for imaging neuroinflammation in Alzheimer's disease and mild cognitive impairment.Frontiers in immunology · 2022Review
- Novel PET Imaging of Inflammatory Targets and Cells for the Diagnosis and Monitoring of Giant Cell Arteritis and Polymyalgia Rheumatica.Frontiers in medicine · 2022Review
- PET Imaging of Neuroinflammation in Alzheimer's Disease.Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors.
Franziska J VettermannDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.
Stefanie HarrisDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.
Julia SchmittDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.
Marcus UnterrainerDepartment of Radiology, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.
Simon LindnerDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.
Boris-Stephan RauchmannDepartment of Radiology, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.ORCID 0000-0003-4547-6240
Carla PalleisDepartment of Neurology, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.
Endy WeidingerDepartment of Neurology, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.
Leonie BeyerDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.ORCID 0000-0002-7358-4495
Florian EckenweberDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.
Sebastian SchusterDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.
Gloria BiecheleDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.
Christian FerschmannDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.
Vladimir M MilenkovicDepartment of Psychiatry and Psychotherapy, University of Regensburg, 93053 Regensburg, Germany.ORCID 0000-0002-6050-8071
Christian H WetzelDepartment of Psychiatry and Psychotherapy, University of Regensburg, 93053 Regensburg, Germany.ORCID 0000-0002-5762-0003
Rainer RupprechtDepartment of Psychiatry and Psychotherapy, University of Regensburg, 93053 Regensburg, Germany.
Daniel JanowitzInstitute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.
Katharina BuergerInstitute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.
Robert PerneczkyDepartment of Psychiatry and Psychotherapy, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.
Günter U HöglingerGerman Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.
Johannes LevinDepartment of Neurology, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.ORCID 0000-0001-5092-4306
Christian HaassGerman Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.ORCID 0000-0002-4869-1627
Joerg C TonnDepartment of Neurosurgery, University Hospital of Munich, 81377 Munich, Germany.
Maximilian NiyaziDepartment of Radiation Oncology, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.
Peter BartensteinDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.
Nathalie L AlbertDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.
Matthias BrendelDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.
Funding
Deutsche Forschungsgemeinschaft 421887978, 422182557, EXC 2145 SyNergy - ID 390857198Hirnliga e.V. Manfred-Strohscheer-StiftungNOMIS foundation FTLD project
Abstract
TSPO-PET tracers are sensitive to a single-nucleotide polymorphism (rs6971-SNP), resulting in low-, medium- and high-affinity binders (LABs, MABs and HABS), but the clinical relevance of [
Indexed as
4R-tauopathyAlzheimer’s diseasemicroglianeurodegenerationneuro-oncologyTSPO-PET
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.