Evidence map›Paper›PMID 34073545›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Hepatocellular Carcinoma Drug-Eluting Bead Transarterial Chemoembolization (DEB-TACE): Outcome Analysis Using a Model Based On Pre-Treatment CT Texture Features.

Marcello Andrea Tipaldi, Edoardo Ronconi, Elena Lucertini, Miltiadis Krokidis, Marta Zerunian, Tiziano Polidori, Paola Begini, Massimo Marignani, Federica Mazzuca, Damiano Caruso and 2 more

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Radiomic Analysis Applied to Pretreatment Gd-EOB-DTPA-enhanced MR Imaging Predicts Response to Selective Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
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  12. Response Assessment of Primary Liver Tumors to Novel Therapies: an Imaging Perspective.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marcello Andrea TipaldiDepartment of Surgical and Medical Sciences and Translational Medicine, Sapienza-University of Rome, 00189 Rome, Italy.
Edoardo RonconiDepartment of Radiology, Sant'Andrea University of Hospital La Sapienza, 00189 Rome, Italy.ORCID 0000-0002-6140-977X
Elena LucertiniDepartment of Radiology, Sant'Andrea University of Hospital La Sapienza, 00189 Rome, Italy.
Miltiadis KrokidisDepartment of Radiology, Areteion Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.ORCID 0000-0002-2191-240X
Marta ZerunianDepartment of Surgical and Medical Sciences and Translational Medicine, Sapienza-University of Rome, 00189 Rome, Italy.ORCID 0000-0003-4635-7999
Tiziano PolidoriDepartment of Radiology, Sant'Andrea University of Hospital La Sapienza, 00189 Rome, Italy.ORCID 0000-0002-4633-6760
Paola BeginiDepartment of Liver Diseases Section, AOU Sant'Andrea Hospital, University of Hospital La Sapienza, 00189 Rome, Italy.
Massimo MarignaniDepartment of Liver Diseases Section, AOU Sant'Andrea Hospital, University of Hospital La Sapienza, 00189 Rome, Italy.
Federica MazzucaDepartment of Clinical and Molecular Oncology-Sapienza, University of Rome, Sant'Andrea University Hospital, via di Grottarossa 1035, 00189 Rome, Italy.
Damiano CarusoDepartment of Radiological Sciences, Oncological and Pathological Sciences, University of Rome Sapienza, Sant'Andrea University Hospital, 00189 Rome, Italy.ORCID 0000-0001-9285-4764
Michele RossiDepartment of Surgical and Medical Sciences and Translational Medicine, Sapienza-University of Rome, 00189 Rome, Italy.
Andrea LaghiDepartment of Surgical and Medical Sciences and Translational Medicine, Sapienza-University of Rome, 00189 Rome, Italy.ORCID 0000-0002-3091-7819

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Introduction and Aim: The aim of this study is to investigate the prognostic value, in terms of response and survival, of CT-based radiomics features for patients with HCC undergoing drug-eluting beads transarterial chemoembolization (DEB-TACE). (2) Materials and Methods: Pre-treatment CT examinations of 50 patients with HCC, treated with DEB-TACE were manually segmented to obtain the tumor volumetric region of interest, extracting radiomics features with TexRAD. Response to therapy evaluation was performed basing on post-procedural CT examination compared to pre-procedural CT, using modified RECIST criteria for HCC. The prognostic value of texture analysis was evaluated, investigating the correlation between radiomics features, response to therapy and overall survival. Three models based on texture and clinical variables and a combination of them were finally built; (3) Results: Entropy, skewness, MPP and kurtosis showed a significant correlation with complete response (CR) to TACE (all

Indexed as

hepatocellular carcinomainterventional oncologyradiomicsTACEtexture analysis

Identifiers

PMID34073545
PMCPMC8226518

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.