Evidence map›Paper›PMID 34073519›Full record

ArticleBiology2021

Biocompatibility and Antibiofilm Properties of Calcium Silicate-Based Cements: An In Vitro Evaluation and Report of Two Clinical Cases.

Maurizio Bossù, Patrizia Mancini, Erika Bruni, Daniela Uccelletti, Adele Preziosi, Marco Rulli, Michela Relucenti, Orlando Donfrancesco, Flavia Iaculli, Gianni Di Giorgio and 3 more

Abstract read
In one paragraph

Article in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Journal of dentistry (Shiraz, Iran) · 2025
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  16. SEM evaluation of dental cement surface morphology and microbial adhesion - a comparative study.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maurizio BossùDepartment of Oral and Maxillofacial Science, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy.
Patrizia ManciniDepartment of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.ORCID 0000-0003-0556-2056
Erika BruniDepartment of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, p.le A. Moro 5, 00185 Rome, Italy.
Daniela UccellettiDepartment of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, p.le A. Moro 5, 00185 Rome, Italy.ORCID 0000-0001-6841-8129
Adele PreziosiDepartment of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.
Marco RulliDepartment of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.
Michela RelucentiDepartment of Anatomical, Histological, Forensic and Orthopaedic Sciences, Section of Human Anatomy, Sapienza University of Rome, Via A. Borelli 50, 00161 Rome, Italy.ORCID 0000-0002-3805-9505
Orlando DonfrancescoDepartment of Oral and Maxillofacial Science, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy.ORCID 0000-0003-4544-8928
Flavia IaculliDepartment of Oral and Maxillofacial Science, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy.
Gianni Di GiorgioDepartment of Oral and Maxillofacial Science, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy.ORCID 0000-0001-6251-4072
Roberto MatassaDepartment of Anatomical, Histological, Forensic and Orthopaedic Sciences, Section of Human Anatomy, Sapienza University of Rome, Via A. Borelli 50, 00161 Rome, Italy.ORCID 0000-0002-6336-4587
Alessandro SalucciDepartment of Oral and Maxillofacial Science, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy.
Antonella PolimeniDepartment of Oral and Maxillofacial Science, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy.ORCID 0000-0002-2679-7607

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium silicate-based cements have reached excellent levels of performance in endodontics, providing predictable and successful results. To better assess the properties of these bioactive materials, the present study aimed to compare the biocompatibility and antibiofilm properties of ProRoot MTA and Biodentine. Human osteogenic sarcoma (Saos-2) cells were cultured on ProRoot MTA and Biodentine samples or in the presence of both cement extracts. Cell viability assay, measurement of reactive oxygen species (ROS), immunofluorescence analysis, as well as morphological evaluations were conducted. Moreover,

Indexed as

antibiofilm propertiesbioactive cementsbiocompatibilitybiodentinemineral trioxide aggregate

Identifiers

PMID34073519
PMCPMC8226987

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.