Evidence map›Paper›PMID 34073518›Full record

ReviewPolymers2021

Recent Advances in Chemically-Modified and Hybrid Carrageenan-Based Platforms for Drug Delivery, Wound Healing, and Tissue Engineering.

Hamidreza Mokhtari, Shima Tavakoli, Fereshteh Safarpour, Mahshid Kharaziha, Hamid Reza Bakhsheshi-Rad, Seeram Ramakrishna, Filippo Berto

Open access · goldAbstract readReview
In one paragraph

Review in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
18.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 126 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 5 countries.

Hamidreza MokhtariDepartment of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.
Shima TavakoliDivision of Polymer Chemistry, Department of Chemistry-Ångstrom Laboratory, Uppsala University, SE75121 Uppsala, Sweden.
Fereshteh SafarpourDepartment of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.
Mahshid KharazihaDepartment of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.ORCID 0000-0002-5782-8007
Hamid Reza Bakhsheshi-RadAdvanced Materials Research Center, Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran.
Seeram RamakrishnaDepartment of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore.ORCID 0000-0001-8479-8686
Filippo BertoDepartment of Mechanical and Industrial Engineering, Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Isfahan University of Technology · IRIslamic Azad University of Najafabad · IRNational University of Singapore · SGNorwegian University of Science and Technology · NOUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, many studies have focused on carrageenan-based hydrogels for biomedical applications thanks to their intrinsic properties, including biodegradability, biocompatibility, resembling native glycosaminoglycans, antioxidants, antitumor, immunomodulatory, and anticoagulant properties. They can easily change to three-dimensional hydrogels using a simple ionic crosslinking process. However, there are some limitations, including the uncontrollable exchange of ions and the formation of a brittle hydrogel, which can be overcome via simple chemical modifications of polymer networks to form chemically crosslinked hydrogels with significant mechanical properties and a controlled degradation rate. Additionally, the incorporation of various types of nanoparticles and polymer networks into carrageenan hydrogels has resulted in the formation of hybrid platforms with significant mechanical, chemical and biological properties, making them suitable biomaterials for drug delivery (DD), tissue engineering (TE), and wound healing applications. Herein, we aim to overview the recent advances in various chemical modification approaches and hybrid carrageenan-based platforms for tissue engineering and drug delivery applications.

Indexed as

carrageenanchemical modificationdrug deliverytissue engineeringwound healing

Identifiers

PMID34073518
PMCPMC8198092
OpenAlexW3165704602

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.