Evidence map›Paper›PMID 34073433›Full record

ArticleBioengineering (Basel, Switzerland)2021

Blood Glucose Level Forecasting on Type-1-Diabetes Subjects during Physical Activity: A Comparative Analysis of Different Learning Techniques.

Benedetta De Paoli, Federico D'Antoni, Mario Merone, Silvia Pieralice, Vincenzo Piemonte, Paolo Pozzilli

Abstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The New Frontiers of Artificial Organ Engineering.Bioengineering (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Benedetta De PaoliUnit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.
Federico D'AntoniUnit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.ORCID 0000-0001-7377-5462
Mario MeroneUnit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.ORCID 0000-0002-9406-2397
Silvia PieraliceUnit of Diabetology and Endocrinology, Department of Medicine, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.
Vincenzo PiemonteUnit of Chemical Engineering, Department of Engineering, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.ORCID 0000-0002-2421-3938
Paolo PozzilliUnit of Diabetology and Endocrinology, Department of Medicine, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundType 1 Diabetes Mellitus (T1DM) is a widespread chronic disease in industrialized countries. Preventing blood glucose levels from exceeding the euglycaemic range would reduce the incidence of diabetes-related complications and improve the quality of life of subjects with T1DM. As a consequence, in the last decade, many Machine Learning algorithms aiming to forecast future blood glucose levels have been proposed. Despite the excellent performance they obtained, the prediction of abrupt changes in blood glucose values produced during physical activity (PA) is still one of the main challenges.

methodsA Jump Neural Network was developed in order to overcome the issue of predicting blood glucose values during PA. Three learning configurations were developed and tested: offline training, online training, and online training with reinforcement. All configurations were tested on six subjects suffering from T1DM that held regular PA (three aerobic and three anaerobic) and exploited Continuous Glucose Monitoring (CGM).

resultsThe forecasting performance was evaluated in terms of the Root-Mean-Squared-Error (RMSE), according to a paradigm of Precision Medicine.

conclusionsThe online learning configurations performed better than the offline configuration in total days but not on the only CGM associated with the PA; thus, the results do not justify the increased computational burden because the improvement was not significant.

Indexed as

diabetesneural networkonline learningphysical activityprecision medicinetime series forecasting

Identifiers

PMID34073433
PMCPMC8229703

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.