Evidence map›Paper›PMID 34073402›Full record

ArticleInternational journal of molecular sciences2021

Evaluation of Polymeric Matrix Loaded with Melatonin for Wound Dressing.

Beata Kaczmarek-Szczepańska, Justyna Ostrowska, Justyna Kozłowska, Zofia Szota, Anna A Brożyna, Rita Dreier, Russel J Reiter, Andrzej T Slominski, Kerstin Steinbrink, Konrad Kleszczyński

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Biopolymeric Scaffolds with Melatonin for Tissue Engineering-A Review.International journal of molecular sciences · 2025
    Review
  4. Effect of melatonin loaded chitosan hydrogel on rat spinal cord injury.Veterinary research forum : an international quarterly journal · 2025
    Article
  5. Hyaluronic Acid/Ellagic Acid as Materials for Potential Medical Application.International journal of molecular sciences · 2024
    Article
  6. Melatonin/Sericin Wound Healing Patches: Implications for Melanoma Therapy.International journal of molecular sciences · 2024
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Beata Kaczmarek-SzczepańskaDepartment of Biomaterials and Cosmetics Chemistry, Faculty of Chemistry, Nicolaus Copernicus University, Gagarin 7, 87-100 Toruń, Poland.ORCID 0000-0002-2563-2376
Justyna OstrowskaDepartment of Biomaterials and Cosmetics Chemistry, Faculty of Chemistry, Nicolaus Copernicus University, Gagarin 7, 87-100 Toruń, Poland.
Justyna KozłowskaDepartment of Biomaterials and Cosmetics Chemistry, Faculty of Chemistry, Nicolaus Copernicus University, Gagarin 7, 87-100 Toruń, Poland.ORCID 0000-0002-2482-339X
Zofia SzotaDepartment of Human Biology, Institute of Biology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, Lwowska 1, 87-100 Toruń, Poland.ORCID 0000-0002-6829-4514
Anna A BrożynaDepartment of Human Biology, Institute of Biology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, Lwowska 1, 87-100 Toruń, Poland.ORCID 0000-0002-3195-9965
Rita DreierInstitute of Physiological Chemistry and Pathobiochemistry, Waldeyerstraße 15, 48149 Münster, Germany.ORCID 0000-0003-1267-8217
Russel J ReiterDepartment of Cellular and Structural Biology, UT Health Science Center, San Antonio, TX 78229, USA.ORCID 0000-0001-6763-4225
Andrzej T SlominskiComprehensive Cancer Center, Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0001-8963-3995
Kerstin SteinbrinkDepartment of Dermatology, University of Münster, Von-Esmarch-Str. 58, 48149 Münster, Germany.
Konrad KleszczyńskiDepartment of Dermatology, University of Münster, Von-Esmarch-Str. 58, 48149 Münster, Germany.
Nicolaus Copernicus University · PLUniversity of Münster · DEThe University of Texas Health Science Center at San Antonio · USUniversity of Alabama at Birmingham · US

Funding

Deutsche Forschungsgemeinschaft KL2900/2-1Nicoluas Copernicus University in Torun 282/2021 IDUB SD
6 · The paper itself

Abstract

The development of scaffolds mimicking the extracellular matrix containing bioactive substances has great potential in tissue engineering and wound healing applications. This study investigates melatonin-a methoxyindole present in almost all biological systems. Melatonin is a bioregulator in terms of its potential clinical importance for future therapies of cutaneous diseases. Mammalian skin is not only a prominent melatonin target, but also produces and rapidly metabolizes the multifunctional methoxyindole to biologically active metabolites. In our methodology, chitosan/collagen (CTS/Coll)-contained biomaterials are blended with melatonin at different doses to fabricate biomimetic hybrid scaffolds. We use rat tail tendon- and

Indexed as

BandagesMelatoninCell LineChitosanCollagenDermisDrug Evaluation, PreclinicalEpidermisFibroblastsHumansKeratinocytesChitosanCollagenMelatoninbiopolymerschitosancollagencutaneous cellsmelatoninscaffoldswound healing

Identifiers

PMID34073402
PMCPMC8197906
OpenAlexW3164784715

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.