ArticleMicroorganisms2021
Molecular Analysis of East African Lumpy Skin Disease Viruses Reveals a Mixed Isolate with Features of Both Vaccine and Field Isolates.
Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Lumpy Skin Disease Virus (LSDV) recently emerged in Egypt: molecular detection, and assessment of the related hematobiochemical, and risk factors.BMC veterinary research · 2026Article
- Article
- Exploring the evolutionary journey of the lumpy skin disease virus through the phylogenetic and phylo-geo network analysis.Frontiers in cellular and infection microbiology · 2025Article
- Characterization of Lumpy Skin Disease in Northern Bangladesh: Clinical, Pathological, Biochemical, and Molecular Perspectives.Veterinary medicine international · 2025Article
- Molecular characterization and phylogenetic analysis of the lumpy skin disease virus isolated in Al-Zawiya, Western Libya.Open veterinary journal · 2025Article
- Detection and molecular characterization of lumpy skin disease and bovine papular stomatitis viruses in lumpy skin disease-suspected outbreaks in Tanzania.Virology journal · 2024Article
- Epidemiology, genetic characterization and population structure analysis of lumpy skin disease virus from North India.Tropical animal health and production · 2024Article
- Characterization and molecular identification of the lumpy skin disease virus in cattle in the Mekong Delta of Vietnam.Open veterinary journal · 2024Article
- Different Neutralizing Antibody Responses of Heterologous Sera on Sheeppox and Lumpy Skin Disease Viruses.Viruses · 2024Article
- Article
- Molecular characterization of recombinant LSDV isolates from 2022 outbreak in Indonesia through phylogenetic networks and whole-genome SNP-based analysis.BMC genomics · 2024Article
- Article
- Article
- First complete genome sequence of lumpy skin disease virus directly from a clinical sample in South India.Virus genes · 2023Article
- Lumpy skin disease: history, current understanding and research gaps in the context of recent geographic expansion.Frontiers in microbiology · 2023Review
- Sign of APOBEC editing, purifying selection, frameshift, and in-frame nonsense mutations in the microevolution of lumpy skin disease virus.Frontiers in microbiology · 2023Article
- Lumpy Skin Disease Outbreaks in Africa, Europe, and Asia (2005-2022): Multiple Change Point Analysis and Time Series Forecast.Viruses · 2022Article
- Development and Optimization of Indirect ELISAs for the Detection of Anti-Capripoxvirus Antibodies in Cattle, Sheep, and Goat Sera.Microorganisms · 2022Article
- Molecular identification and characterization of Lumpy skin disease virus emergence from cattle in the northeastern part of Thailand.Journal of veterinary science · 2022Article
- An in-depth bioinformatic analysis of the novel recombinant lumpy skin disease virus strains: from unique patterns to established lineage.BMC genomics · 2022Article
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Authors and funding
14 authors at 7 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lumpy skin disease (LSD), an economically significant disease in cattle caused by lumpy skin disease virus (LSDV), is endemic to nearly all of Africa. Since 2012, LSDV has emerged as a significant epizootic pathogen given its rapid spread into new geographical locations outside Africa, including the Middle East, Eastern Europe, and Asia. To assess the genetic diversity of LSDVs in East Africa, we sequenced and analyzed the RPO30 and GPCR genes of LSDV in twenty-two archive samples collected in Ethiopia, Kenya, and Sudan before the appearance of LSD in the Middle East and its incursion into Europe. We compared them to publicly available sequences of LSDVs from the same region and those collected elsewhere. The results showed that the East African field isolates in this study were remarkably similar to each other and to previously sequenced field isolates of LSDV for the RPO30 and GPCR genes. The only exception was LSDV Embu/B338/2011, a field virus collected in Kenya, which displayed mixed features between the LSDV Neethling vaccine and field isolates. LSDV Embu/B338/2011 had the same 12-nucleotide insertion found in LSDV Neethling and KS-1 vaccines. Further analysis of the partial EEV glycoprotein, B22R, RNA helicase, virion core protein, NTPase, and N1R/p28-like protein genes showed that LSDV Embu/B338/2011 differs from previously described LSDV variants carrying the 12-nucleotide insertion in the GPCR gene. These findings highlight the importance of the constant monitoring of genetic variation among LSDV isolates.
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