Evidence map›Paper›PMID 34073294›Full record

ArticleCells2021

Loss of Motor Protein MYO1C Causes Rhodopsin Mislocalization and Results in Impaired Visual Function.

Ashish K Solanki, Manas R Biswal, Stephen Walterhouse, René Martin, Altaf A Kondkar, Hans-Joachim Knölker, Bushra Rahman, Ehtesham Arif, Shahid Husain, Sandra R Montezuma and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. C9ORF72 Deficiency Results in Neurodegeneration in the Zebrafish Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Ashish K SolankiDepartment of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.ORCID 0000-0002-5043-1699
Manas R BiswalDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0002-9685-2923
Stephen WalterhouseDepartment of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
René MartinFaculty of Chemistry, Technische Universität Dresden, Bergstraße 66, 01069 Dresden, Germany.
Altaf A KondkarDepartment of Ophthalmology, College of Medicine, King Saud University, Riyadh 11411, Saudi Arabia.ORCID 0000-0002-5516-6951
Hans-Joachim KnölkerFaculty of Chemistry, Technische Universität Dresden, Bergstraße 66, 01069 Dresden, Germany.ORCID 0000-0002-9631-5239
Bushra RahmanDepartment of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Ehtesham ArifDepartment of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Shahid HusainDepartment of Ophthalmology, Medical University of South Carolina, Charleston, SC 29425, USA.ORCID 0000-0002-8978-8353
Sandra R MontezumaDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, 516 Delaware Street S.E., 9th Floor, Minneapolis, MN 55455, USA.
Deepak NihalaniNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bldg. 2DEM, Room 6085, 6707 Democracy Blvd., Bethesda, MD 20817, USA.
Glenn Prazere LoboDepartment of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Medical University of South Carolina · USTechnische Universität Dresden · DEUniversity of Minnesota · USKing Saud University · SANational Institutes of Health · USUniversity of South Florida · US

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
Myo1c Participates in Podocyte Junction Formation Through Interaction with Neph1R01DK087956 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI NIHALANI, DEEPAK · 2010 to 2018
$3.5M
Physiological Role of the Vitamin A Transporter RBPR2 for VisionR01EY030889 · NEI · UNIVERSITY OF MINNESOTA · PI LOBO, GLENN P · 2020 to 2024
$1.8M
Opioid-Induced RGC Neuroprotection via Changes in Protein AcetylationR01EY027355 · NEI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HUSAIN, SHAHID · 2017 to 2020
$1.5M
Defining oxidative stress induced changes in RPE that control RPE and photoreceptor degenerationR00EY027013 · NEI · UNIVERSITY OF SOUTH FLORIDA · PI BISWAL, MANAS R · 2019 to 2021
$960k
Physiological Role of the Zebrafish Retinol Receptor rbpr2 in VisionR21EY025034 · NEI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LOBO, GLENN P · 2015 to 2016
$436k
Defining oxidative stress induced changes in RPE that control RPE and photoreceptor degenerationK99EY027013 · NEI · UNIVERSITY OF FLORIDA · PI BISWAL, MANAS R · 2016 to 2017
$258k
Clinical Assessment of a novel non-invasive assay for diagnosing recurrent focal and segmental glomerulosclerosisR03TR003038 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ARIF, EHTESHAM · 2019 to 2020
$150k
Preclinical therapeutic validation of a novel therapeutic lead for treating glomerular diseases such as focal and segmental glomerulosclerosisR56DK116887 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI NIHALANI, DEEPAK, SCHNELLMANN, RICK G · 2018 to 2018
$100k
NCATS NIH HHS R03 TR003038NCATS NIH HHS UL1 TR001450NEI NIH HHS K99 EY027013NEI NIH HHS R00 EY027013NEI NIH HHS R01 EY027355NEI NIH HHS R01 EY030889NEI NIH HHS R21 EY025034NIDDK NIH HHS R01 DK087956NIDDK NIH HHS R56 DK116887
6 · The paper itself

Abstract

Unconventional myosins, linked to deafness, are also proposed to play a role in retinal cell physiology. However, their direct role in photoreceptor function remains unclear. We demonstrate that systemic loss of the unconventional myosin MYO1C in mice, specifically causes rhodopsin mislocalization, leading to impaired visual function. Electroretinogram analysis of

Indexed as

AnimalsDyneinsElectroretinographyEye ProteinsMicePhenotypePhotoreceptor CellsRetinaRhodopsinDyneinsEye ProteinsRhodopsinmotor proteinmyosin 1Couter segmentsphotoreceptorretinarhodopsinvisual function

Identifiers

PMID34073294
PMCPMC8229726
OpenAlexW3164878623

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.