Evidence map›Paper›PMID 34073293›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Nrf2 Regulates Anti-Inflammatory

Haranatha R Potteti, Lalith K Venkareddy, Patrick M Noone, Aparna Ankireddy, Chandramohan R Tamatam, Dolly Mehta, Chinnaswamy Tiruppathi, Sekhar P Reddy

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Haranatha R PottetiDepartments of Pediatrics, University of Illinois, Chicago, IL 60612, USA.
Lalith K VenkareddyDepartments of Pediatrics, University of Illinois, Chicago, IL 60612, USA.
Patrick M NooneDepartments of Pediatrics, University of Illinois, Chicago, IL 60612, USA.
Aparna AnkireddyDepartments of Pediatrics, University of Illinois, Chicago, IL 60612, USA.
Chandramohan R TamatamDepartments of Pediatrics, University of Illinois, Chicago, IL 60612, USA.
Dolly MehtaDepartment of Pharmacology, University of Illinois, Chicago, IL 60612, USA.
Chinnaswamy TiruppathiDepartment of Pharmacology, University of Illinois, Chicago, IL 60612, USA.
Sekhar P ReddyDepartments of Pediatrics, University of Illinois, Chicago, IL 60612, USA.
University of Illinois Chicago · US

Funding

Role of Nrf2 in Alveolar Epithelial Cell Regeneration During Lung RepairR01HL136946 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI REDDY, SEKHAR P. · 2017 to 2020
$2.1M
Fra-1-A20 Signaling and Resolution of Pneumonia-Induced SepsisR01GM124235 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI REDDY, SEKHAR P. · 2017 to 2020
$1.3M
NHLBI NIH HHS R01 HL136946NHLBI NIH HHS R01HL136946NIGMS NIH HHS R01 GM124235NIGMS NIH HHS R01GM124235
6 · The paper itself

Abstract

The aberrant regulation of inflammatory gene transcription following oxidant and inflammatory stimuli can culminate in unchecked systemic inflammation leading to organ dysfunction. The Nrf2 transcription factor dampens cellular stress and controls inflammation by upregulating antioxidant gene expression and TNFα-induced Protein 3 (TNFAIP3, aka A20) deubiquitinase by controlling NF-kB signaling dampens tissue inflammation. Here, we report that Nrf2 is required for

Indexed as

deubiquitinaseendotoxinInflammationlungmacrophages

Identifiers

PMID34073293
PMCPMC8228212
OpenAlexW3165170571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.