Evidence map›Paper›PMID 34073258›Full record

ReviewCancers2021

Emerging Next-Generation Target for Cancer Immunotherapy Research: The Orphan Nuclear Receptor NR2F6.

Victoria Klepsch, Kerstin Siegmund, Gottfried Baier

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Regulation of PD-L1 Expression by Nuclear Receptors.International journal of molecular sciences · 2023
    Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Victoria KlepschInstitute for Translational Cell Genetics, Medical University Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-4146-4664
Kerstin SiegmundInstitute for Translational Cell Genetics, Medical University Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-3654-1170
Gottfried BaierInstitute for Translational Cell Genetics, Medical University Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-2085-8325
Innsbruck Medical University · AT

Funding

Austrian Central Bank Jubiläumsfonds 17551Austrian Science Fund P30321-B21Austrian Science Fund P31383-B30Austrian Science Fund P34368-BAustrian Science Fund TAI 88Austrian Science Fund FWF P 30324Austrian Science Fund FWF P 31383Austrian Science Fund FWF TAI 88European Research Council 786462Medizinische Universität Innsbruck Legerlotz StiftungOpen Access Funding by the Austrian Science Fund (FWF) P30321-B21
6 · The paper itself

Abstract

Additional therapeutic targets suitable for boosting anti-tumor effector responses have been found inside effector CD4

Indexed as

alternative and druggable cancer immune checkpointNR2F6 inhibition as first-in-class cancer immunotherapy conceptorphan nuclear receptor NR2F6transcriptional repressor of CD4+ and CD8+ effector but not regulatory T cell functionstumor immunologytumor-promoting function

Identifiers

PMID34073258
PMCPMC8197903
OpenAlexW3164735656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.