Evidence map›Paper›PMID 34073122›Full record

ArticleLife (Basel, Switzerland)2021

Spatiotemporal 22q11.21 Protein Network Implicates DGCR8-Dependent MicroRNA Biogenesis as a Risk for Late-Fetal Cortical Development in Psychiatric Diseases.

Liang Chen, Wenxiang Cai, Weidi Wang, Zhe Liu, Guan Ning Lin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Decoding microRNAs in autism spectrum disorder.Molecular therapy. Nucleic acids · 2022
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Liang ChenSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
Wenxiang CaiSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
Weidi WangSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
Zhe LiuSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
Guan Ning LinSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
Shanghai Jiao Tong University · CN

Funding

National Natural Science Foundation of China No. 81671328, 81971292
6 · The paper itself

Abstract

Chromosome 22q11.21 copy number variant (CNV) is a vital risk factor that can be a genetic predisposition to neurodevelopmental disorders (NDD). As 22q11.21 CNV affects multiple genes, causal disease genes and mechanisms affected are still poorly understood. Thus, we aimed to identify the most impactful 22q11.21 CNV genes and the potential impacted human brain regions, developmental stages, and signaling pathways. We constructed the spatiotemporal dynamic networks of 22q11.21 CNV genes using the brain developmental transcriptome and physical protein-protein interactions. The affected brain regions, developmental stages, driver genes, and pathways were subsequently investigated via integrated bioinformatics analysis. As a result, we first identified that 22q11.21 CNV genes affect cortical area mainly during late-fetal periods. Interestingly, we observed that connections between a driver gene

Indexed as

chromosome 22q11.21CNVDGCR8PPIspatiotemporal network

Identifiers

PMID34073122
PMCPMC8227527
OpenAlexW3164646027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.