Evidence map›Paper›PMID 34073043›Full record

ArticleInternational journal of molecular sciences2021

Treatment with a GSK-3β/HDAC Dual Inhibitor Restores Neuronal Survival and Maturation in an In Vitro and In Vivo Model of

Manuela Loi, Laura Gennaccaro, Claudia Fuchs, Stefania Trazzi, Giorgio Medici, Giuseppe Galvani, Nicola Mottolese, Marianna Tassinari, Roberto Rimondini Giorgini, Andrea Milelli and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Expression of a Secretable, Cell-Penetrating CDKL5 Protein Enhances the Efficacy of Gene Therapy for CDKL5 Deficiency Disorder.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Article
  5. Article
  6. Article
  7. Rare Monogenic Diseases: Molecular Pathophysiology and Novel Therapies.International journal of molecular sciences · 2022
    Article
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Manuela LoiDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.
Laura GennaccaroDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.ORCID 0000-0002-0438-2152
Claudia FuchsDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.
Stefania TrazziDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.
Giorgio MediciDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.
Giuseppe GalvaniDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.ORCID 0000-0002-4533-9134
Nicola MottoleseDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.
Marianna TassinariDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.
Roberto Rimondini GiorginiDepartment of Medical and Clinical Sciences, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0003-4099-513X
Andrea MilelliDepartment for Life Quality Studies, University of Bologna, 47921 Rimini, Italy.ORCID 0000-0003-2285-7403
Elisabetta CianiDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.
University of Bologna · IT

Funding

Fondazione Telethon GGP19045Italian association:CDKL5 insieme verso la cura Ciani
6 · The paper itself

Abstract

Mutations in the X-linked cyclin-dependent kinase-like 5 (

Indexed as

Histone Deacetylase InhibitorsAnimalsCell LineCell SurvivalEpileptic SyndromesGlycogen Synthase Kinase 3 betaHippocampusHumansMiceMice, Inbred C57BLMice, KnockoutNeuronsSpasms, InfantileGlycogen Synthase Kinase 3 betaHistone Deacetylase InhibitorsCDKL5 deficiency disorderdual inhibitorGSK-3βHDAC6hippocampal defectsneuronal survivalsynapse development

Identifiers

PMID34073043
PMCPMC8198396
OpenAlexW3165262664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.