Evidence map›Paper›PMID 34072960›Full record

ReviewBiomolecules2021

Understanding Emotions: Origins and Roles of the Amygdala.

Goran Šimić, Mladenka Tkalčić, Vana Vukić, Damir Mulc, Ena Španić, Marina Šagud, Francisco E Olucha-Bordonau, Mario Vukšić, Patrick R Hof

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 221 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
221citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

221 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  3. Biopsychosocial and Environmental Factors That Impact Brain-Gut-Microbiome Interactions in Obesity.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026
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161 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Goran ŠimićDepartment of Neuroscience, Croatian Institute for Brain Research, University of Zagreb Medical School, 10000 Zagreb, Croatia.ORCID 0000-0002-6339-9261
Mladenka TkalčićDepartment of Psychology, Faculty of Humanities and Social Sciences, University of Rijeka, 51000 Rijeka, Croatia.
Vana VukićDepartment of Neuroscience, Croatian Institute for Brain Research, University of Zagreb Medical School, 10000 Zagreb, Croatia.
Damir MulcUniversity Psychiatric Hospital Vrapče, 10090 Zagreb, Croatia.
Ena ŠpanićDepartment of Neuroscience, Croatian Institute for Brain Research, University of Zagreb Medical School, 10000 Zagreb, Croatia.
Marina ŠagudDepartment of Psychiatry, Clinical Hospital Center Zagreb and University of Zagreb School of Medicine, 10000 Zagreb, Croatia.ORCID 0000-0001-9620-2181
Francisco E Olucha-BordonauDepartment of Medicine, School of Medical Sciences, Universitat Jaume I, 12071 Castellón de la Plana, Spain.ORCID 0000-0003-0342-993X
Mario VukšićDepartment of Neuroscience, Croatian Institute for Brain Research, University of Zagreb Medical School, 10000 Zagreb, Croatia.
Patrick R HofNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 07305, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emotions arise from activations of specialized neuronal populations in several parts of the cerebral cortex, notably the anterior cingulate, insula, ventromedial prefrontal, and subcortical structures, such as the amygdala, ventral striatum, putamen, caudate nucleus, and ventral tegmental area. Feelings are conscious, emotional experiences of these activations that contribute to neuronal networks mediating thoughts, language, and behavior, thus enhancing the ability to predict, learn, and reappraise stimuli and situations in the environment based on previous experiences. Contemporary theories of emotion converge around the key role of the amygdala as the central subcortical emotional brain structure that constantly evaluates and integrates a variety of sensory information from the surroundings and assigns them appropriate values of emotional dimensions, such as valence, intensity, and approachability. The amygdala participates in the regulation of autonomic and endocrine functions, decision-making and adaptations of instinctive and motivational behaviors to changes in the environment through implicit associative learning, changes in short- and long-term synaptic plasticity, and activation of the fight-or-flight response via efferent projections from its central nucleus to cortical and subcortical structures.

Indexed as

AmygdalaEmotionsHumansamygdalaanxietyemotionevolutionfear

Identifiers

PMID34072960
PMCPMC8228195

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.