Evidence map›Paper›PMID 34072959›Full record

ReviewInternational journal of molecular sciences2021

Current Strategies for the Regeneration of Skeletal Muscle Tissue.

Emine Alarcin, Ayca Bal-Öztürk, Hüseyin Avci, Hamed Ghorbanpoor, Fatma Dogan Guzel, Ali Akpek, Gözde Yesiltas, Tuba Canak-Ipek, Meltem Avci-Adali

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Review
  3. Effects ofBiology · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. A novel protocol for the direct isolation of a highly pure and regenerative population of satellite stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Tissue Engineered 3D Constructs for Volumetric Muscle Loss.Annals of biomedical engineering · 2024
    Review
  15. Review
  16. Development of porcine skeletal muscle extracellular matrix-derived hydrogels with improved properties and low immunogenicity.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emine AlarcinDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Marmara University, 34854 Istanbul, Turkey.
Ayca Bal-ÖztürkDepartment of Analytical Chemistry, Faculty of Pharmacy, Istinye University, 34010 Istanbul, Turkey.
Hüseyin AvciDepartment of Metallurgical and Materials Engineering Eskisehir Osmangazi University, 26040 Eskisehir, Turkey.ORCID 0000-0002-2475-1963
Hamed GhorbanpoorAvciBio Research Group, Eskisehir Osmangazi University, 26040 Eskisehir, Turkey.
Fatma Dogan GuzelDepartment of Biomedical Engineering, Ankara Yildirim Beyazit University, 06010 Ankara, Turkey.
Ali AkpekDepartment of Bioengineering, Gebze Technical University, 41400 Gebze, Turkey.ORCID 0000-0003-2803-6585
Gözde YesiltasDepartment of Bioengineering, Gebze Technical University, 41400 Gebze, Turkey.
Tuba Canak-IpekDepartment of Thoracic and Cardiovascular Surgery, University Hospital Tuebingen, Calwerstraße 7/1, 72076 Tuebingen, Germany.
Meltem Avci-AdaliDepartment of Thoracic and Cardiovascular Surgery, University Hospital Tuebingen, Calwerstraße 7/1, 72076 Tuebingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic injuries, tumor resections, and degenerative diseases can damage skeletal muscle and lead to functional impairment and severe disability. Skeletal muscle regeneration is a complex process that depends on various cell types, signaling molecules, architectural cues, and physicochemical properties to be successful. To promote muscle repair and regeneration, various strategies for skeletal muscle tissue engineering have been developed in the last decades. However, there is still a high demand for the development of new methods and materials that promote skeletal muscle repair and functional regeneration to bring approaches closer to therapies in the clinic that structurally and functionally repair muscle. The combination of stem cells, biomaterials, and biomolecules is used to induce skeletal muscle regeneration. In this review, we provide an overview of different cell types used to treat skeletal muscle injury, highlight current strategies in biomaterial-based approaches, the importance of topography for the successful creation of functional striated muscle fibers, and discuss novel methods for muscle regeneration and challenges for their future clinical implementation.

Indexed as

Biocompatible MaterialsMuscle, SkeletalRegenerationTissue ScaffoldsAnimalsCell LineHumansMuscular DiseasesTissue EngineeringBiocompatible Materialshydrogelsscaffold topographiesskeletal muscle cellstissue engineering

Identifiers

PMID34072959
PMCPMC8198586

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.