Evidence map›Paper›PMID 34072947›Full record

ArticleNutrients2021

Amino Acid-Based Diet Prevents Lethal Infectious Diarrhea by Maintaining Body Water Balance in a Murine

Tatsuki Kimizuka, Natsumi Seki, Genki Yamaguchi, Masahiro Akiyama, Seiichiro Higashi, Koji Hase, Yun-Gi Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Amino acids in piglet diarrhea: Effects, mechanisms and insights.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tatsuki KimizukaResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.
Natsumi SekiResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.
Genki YamaguchiResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.
Masahiro AkiyamaResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.
Seiichiro HigashiCo-Creation Center, Meiji Holdings Co., Ltd., Tokyo 192-0919, Japan.
Koji HaseDivision of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.
Yun-Gi KimResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.ORCID 0000-0003-4251-1848
Keio University · JPMeiji (Japan) · JP

Funding

Japan Agency for Medical Research and Development JP18gm6010004h0003Japan Society for the Promotion of Science JP17H05068Japan Society for the Promotion of Science JP20H03490Yakult Bio-Science Foundation
6 · The paper itself

Abstract

Infectious diarrhea is one of the most important health problems worldwide. Although nutritional status influences the clinical manifestation of various enteric pathogen infections, the effect of diet on enteric infectious diseases remains unclear. Using a fatal infectious diarrheal model, we found that an amino acid-based diet (AD) protected susceptible mice infected with the enteric pathogen

Indexed as

Body WaterAmino AcidsAnimalsCitrobacter rodentiumDiarrheaDietDisease Models, AnimalEnterobacteriaceae InfectionsFemaleMiceMice, Inbred C3HAmino Acidsamino acid-based dietCitrobacter rodentiumdehydrationdiarrheaenteric infection

Identifiers

PMID34072947
PMCPMC8227537
OpenAlexW3165741473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.