Evidence map›Paper›PMID 34072930›Full record

ReviewJournal of personalized medicine2021

Cannabinoids and Inflammations of the Gut-Lung-Skin Barrier.

Cristian Scheau, Constantin Caruntu, Ioana Anca Badarau, Andreea-Elena Scheau, Anca Oana Docea, Daniela Calina, Ana Caruntu

Abstract readReview
In one paragraph

Review in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Article
  2. Review
  3. Impact of Preexisting Substance Use Disorders on Prolonged Opioid Use and Postoperative Complications After Burns.Journal of burn care & research : official publication of the American Burn Association · 2025
    Article
  4. Anti-Infective Screening of Selected Nine Cannabinoids AgainstCurrent issues in molecular biology · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Role of Cannabinoids in Oral Cancer.International journal of molecular sciences · 2024
    Review
  9. Article
  10. Kaempferol: A Review of Current Evidence of Its Antiviral Potential.International journal of molecular sciences · 2023
    Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. The Polypharmacological Effects of Cannabidiol.Molecules (Basel, Switzerland) · 2023
    Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cristian ScheauDepartment of Physiology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0000-0001-7676-6393
Constantin CaruntuDepartment of Physiology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0000-0003-4530-7965
Ioana Anca BadarauDepartment of Physiology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Andreea-Elena ScheauDepartment of Radiology and Medical Imaging, Fundeni Clinical Institute, 022328 Bucharest, Romania.
Anca Oana DoceaDepartment of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.ORCID 0000-0002-8162-5955
Daniela CalinaDepartment of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.ORCID 0000-0002-1523-9116
Ana CaruntuDepartment of Oral and Maxillofacial Surgery, "Carol Davila" Central Military Emergency Hospital, 010825 Bucharest, Romania.ORCID 0000-0003-4200-3069

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies have identified great similarities and interferences between the epithelial layers of the digestive tract, the airways and the cutaneous layer. The relationship between these structures seems to implicate signaling pathways, cellular components and metabolic features, and has led to the definition of a gut-lung-skin barrier. Inflammation seems to involve common features in these tissues; therefore, analyzing the similarities and differences in the modulation of its biomarkers can yield significant data promoting a better understanding of the particularities of specific signaling pathways and cellular effects. Cannabinoids are well known for a wide array of beneficial effects, including anti-inflammatory properties. This paper aims to explore the effects of natural and synthetic cannabinoids, including the components of the endocannabinoid system, in relation to the inflammation of the gut-lung-skin barrier epithelia. Recent advancements in the use of cannabinoids as anti-inflammatory substances in various disorders of the gut, lungs and skin are detailed. Some studies have reported mixed or controversial results, and these have also been addressed in our paper.

Indexed as

cannabinoidsgut-lung-skin barrierinflammationinflammatory biomarkerssignaling pathways

Identifiers

PMID34072930
PMCPMC8227007

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.