Evidence map›Paper›PMID 34072765›Full record

ReviewMolecules (Basel, Switzerland)2021

Developments in Treatment Methodologies Using Dendrimers for Infectious Diseases.

Nina Filipczak, Satya Siva Kishan Yalamarty, Xiang Li, Farzana Parveen, Vladimir Torchilin

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
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  4. Mannosylated PAMAM G2 dendrimers mediated rate programmed delivery of efavirenz target HIV viral latency at reservoirs.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 4 countries.

Nina FilipczakCenter for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA.
Satya Siva Kishan YalamartyCenter for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA.
Xiang LiCenter for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA.
Farzana ParveenCenter for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA.ORCID 0000-0002-3292-3841
Vladimir TorchilinCenter for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA.
Northeastern University · USJiangxi University of Traditional Chinese Medicine · CN

Funding

Lipid-dendrimer micellar nanocarriers for siRNA/drug co-delivery in MDR cancerR01CA200844 · NCI · NORTHEASTERN UNIVERSITY · PI TORCHILIN, VLADIMIR P · 2016 to 2020
$1.7M
NCI NIH HHS R01 CA200844
6 · The paper itself

Abstract

Dendrimers comprise a specific group of macromolecules, which combine structural properties of both single molecules and long expanded polymers. The three-dimensional form of dendrimers and the extensive possibilities for use of additional substrates for their construction creates a multivalent potential and a wide possibility for medical, diagnostic and environmental purposes. Depending on their composition and structure, dendrimers have been of interest in many fields of science, ranging from chemistry, biotechnology to biochemical applications. These compounds have found wide application from the production of catalysts for their use as antibacterial, antifungal and antiviral agents. Of particular interest are peptide dendrimers as a medium for transport of therapeutic substances: synthetic vaccines against parasites, bacteria and viruses, contrast agents used in MRI, antibodies and genetic material. This review focuses on the description of the current classes of dendrimers, the methodology for their synthesis and briefly drawbacks of their properties and their use as potential therapies against infectious diseases.

Indexed as

AnimalsAnti-HIV AgentsAnti-Infective AgentsBacterial InfectionsBiotechnologyCatalysisCommunicable DiseasesContrast MediaCOVID-19 Drug TreatmentDendrimersDrug Delivery SystemsDrug DesignHIV InfectionsHumansInfectious Disease MedicineMagnetic Resonance ImagingAnti-HIV AgentsAnti-Infective AgentsContrast MediaDendrimersPAMAM StarburstPeptidesPolymerspoly(propyleneimine)Polypropylenesantimicrobial therapyantiviral therapydendrimersdiagnosticsdrug deliveryinfectious diseasesnanoparticles

Identifiers

PMID34072765
PMCPMC8198206
OpenAlexW3164304827

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.