Evidence map›Paper›PMID 34072733›Full record

ArticleMolecules (Basel, Switzerland)2021

Droplet Microfluidic Optimisation Using Micropipette Characterisation of Bio-Instructive Polymeric Surfactants.

Charlotte A Henshaw, Adam A Dundas, Valentina Cuzzucoli Crucitti, Morgan R Alexander, Ricky Wildman, Felicity R A J Rose, Derek J Irvine, Philip M Williams

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Charlotte A HenshawMolecular Therapeutics and Formulation, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
Adam A DundasAdvanced Materials and Healthcare Technologies, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
Valentina Cuzzucoli CrucittiCentre for Additive Manufacturing, Department for Chemical and Environmental Engineering, Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK.
Morgan R AlexanderAdvanced Materials and Healthcare Technologies, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
Ricky WildmanCentre for Additive Manufacturing, Department for Chemical and Environmental Engineering, Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK.
Felicity R A J RoseRegenerative Medicine and Cellular Therapies, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
Derek J IrvineCentre for Additive Manufacturing, Department for Chemical and Environmental Engineering, Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK.
Philip M WilliamsMolecular Therapeutics and Formulation, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
University of Nottingham · GB

Funding

Engineering and Physical Sciences Research Council EP/N006615/1
6 · The paper itself

Abstract

Droplet microfluidics can produce highly tailored microparticles whilst retaining monodispersity. However, these systems often require lengthy optimisation, commonly based on a trial-and-error approach, particularly when using bio-instructive, polymeric surfactants. Here, micropipette manipulation methods were used to optimise the concentration of bespoke polymeric surfactants to produce biodegradable (poly(d,l-lactic acid) (PDLLA)) microparticles with unique, bio-instructive surface chemistries. The effect of these three-dimensional surfactants on the interfacial tension of the system was analysed. It was determined that to provide adequate stabilisation, a low level (0.1% (

Indexed as

Drug CarriersBiocompatible MaterialsBiodegradation, EnvironmentalDrug CompoundingLactic AcidMicrofluidicsMicroscopy, Electron, ScanningParticle SizePolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerPolymersPolyvinyl AlcoholSolventsSurface-Active AgentsSurface PropertiesSurface TensionBiocompatible MaterialsDrug CarriersLactic AcidPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerPolymersPolyvinyl AlcoholSolventsSurface-Active Agentsbiodegradablebiomaterialsinterfacial tensionmicrofluidicsmicroparticlemicropipetteparticle synthesissurfactants

Identifiers

PMID34072733
PMCPMC8197901
OpenAlexW3165676271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.