Evidence map›Paper›PMID 34072692›Full record

ArticleJournal of functional morphology and kinesiology2021

Aerobic Exercise Induces Alternative Splicing of Neurexins in Frontal Cortex.

Elisa Innocenzi, Ida Cariati, Emanuela De Domenico, Erika Tiberi, Giovanna D'Arcangelo, Veronica Verdile, Maria Paola Paronetto, Virginia Tancredi, Marco Barchi, Pellegrino Rossi and 2 more

Abstract read
In one paragraph

Article in Journal of functional morphology and kinesiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Open medicine (Warsaw, Poland) · 2024
    Review
  10. Neurexins and their ligands at inhibitory synapses.Frontiers in synaptic neuroscience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Elisa InnocenziDepartment of Biomedicine and Prevention, "Tor Vergata" University of Rome, Via Montpellier 1, 00133 Rome, Italy.
Ida CariatiDepartment of Clinical Sciences and Translational Medicine, "Tor Vergata" University of Rome, Via Montpellier 1, 00133 Rome, Italy.ORCID 0000-0002-2102-5034
Emanuela De DomenicoDepartment of Biomedicine and Prevention, "Tor Vergata" University of Rome, Via Montpellier 1, 00133 Rome, Italy.
Erika TiberiDepartment of Systems Medicine, "Tor Vergata" University of Rome, Via Montpellier 1, 00133 Rome, Italy.ORCID 0000-0001-5388-8312
Giovanna D'ArcangeloDepartment of Systems Medicine, "Tor Vergata" University of Rome, Via Montpellier 1, 00133 Rome, Italy.ORCID 0000-0002-2105-0395
Veronica VerdileDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", Via dei Robilant 1, 00135 Rome, Italy.
Maria Paola ParonettoDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", Via dei Robilant 1, 00135 Rome, Italy.ORCID 0000-0001-5324-0903
Virginia TancrediDepartment of Systems Medicine, "Tor Vergata" University of Rome, Via Montpellier 1, 00133 Rome, Italy.ORCID 0000-0003-4779-2212
Marco BarchiDepartment of Biomedicine and Prevention, "Tor Vergata" University of Rome, Via Montpellier 1, 00133 Rome, Italy.ORCID 0000-0003-1104-6234
Pellegrino RossiDepartment of Biomedicine and Prevention, "Tor Vergata" University of Rome, Via Montpellier 1, 00133 Rome, Italy.
Claudio SetteLaboratory of Cellular and Molecular Neurobiology, IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64, 00143 Rome, Italy.
Paola GrimaldiDepartment of Biomedicine and Prevention, "Tor Vergata" University of Rome, Via Montpellier 1, 00133 Rome, Italy.ORCID 0000-0001-6724-7604

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aerobic exercise (AE) is known to produce beneficial effects on brain health by improving plasticity, connectivity, and cognitive functions, but the underlying molecular mechanisms are still limited. Neurexins (Nrxns) are a family of presynaptic cell adhesion molecules that are important in synapsis formation and maturation. In vertebrates, three-neurexin genes (NRXN1, NRXN2, and NRXN3) have been identified, each encoding for α and β neurexins, from two independent promoters. Moreover, each

Indexed as

alternative splicingexercisefrontal cortexhippocampusneurexinssynapsis

Identifiers

PMID34072692
PMCPMC8261640

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.