Evidence map›Paper›PMID 34072630›Full record

ArticleNutrients2021

Daily Oral Supplementation with 60 mg of Elemental Iron for 12 Weeks Alters Blood Mitochondrial DNA Content, but Not Leukocyte Telomere Length in Cambodian Women.

Shannon L Steele, Anthony Y Y Hsieh, Izabella Gadawski, Hou Kroeun, Susan I Barr, Angela M Devlin, Hélène C F Côté, Crystal D Karakochuk

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Shannon L SteeleFood, Nutrition and Health, University of British Columbia, 2205 East Mall, Vancouver, BC V6T 1Z4, Canada.
Anthony Y Y HsiehDepartment of Pathology and Laboratory Medicine, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 1Z7, Canada.
Izabella GadawskiDepartment of Pathology and Laboratory Medicine, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 1Z7, Canada.
Hou KroeunHelen Keller International, Street 476, Phnom Penh 12301, Cambodia.
Susan I BarrFood, Nutrition and Health, University of British Columbia, 2205 East Mall, Vancouver, BC V6T 1Z4, Canada.ORCID 0000-0001-8701-7152
Angela M DevlinBC Children's Hospital Research Institute, 938 West 28th Ave, Vancouver, BC V5Z 4H4, Canada.
Hélène C F CôtéDepartment of Pathology and Laboratory Medicine, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 1Z7, Canada.
Crystal D KarakochukFood, Nutrition and Health, University of British Columbia, 2205 East Mall, Vancouver, BC V6T 1Z4, Canada.ORCID 0000-0002-1025-2194
University of British Columbia · CAPhnom Penh International University · KH

Funding

CIHR N/AInternational Life Sciences Institute N/AMichael Smith Foundation for Health Research Scholar AwardMicronutrient Initiative N/ASight and Life Foundation N/A
6 · The paper itself

Abstract

There is limited evidence regarding the potential risk of untargeted iron supplementation, especially among individuals who are iron-replete or have genetic hemoglobinopathies. Excess iron exposure can increase the production of reactive oxygen species, which can lead to cellular damage. We evaluated the effect of daily oral supplementation on relative leukocyte telomere length (rLTL) and blood mitochondrial DNA (mtDNA) content in non-pregnant Cambodian women (18-45 years) who received 60 mg of elemental iron as ferrous sulfate (

Indexed as

Dietary SupplementsDNA, MitochondrialIronAdultAntioxidantsCambodiaFemaleHumansLeukocytesOxidative StressTelomereYoung AdultAntioxidantsDNA, MitochondrialIronCambodiacellular damageironleukocyte telomere lengthmitochondrial DNA contentoxidative stresssupplementationwomen

Identifiers

PMID34072630
PMCPMC8227094
OpenAlexW3164647412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.