Evidence map›Paper›PMID 34072569›Full record

ArticleViruses2021

Characterization of a Novel SARS-CoV-2 Genetic Variant with Distinct Spike Protein Mutations.

Anna Gladkikh, Anna Dolgova, Vladimir Dedkov, Valeriya Sbarzaglia, Olga Kanaeva, Anna Popova, Areg Totolian

Abstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. SARS-CoV-2 Variants Monitoring Using Real-Time PCR.Diagnostics (Basel, Switzerland) · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anna GladkikhSaint Petersburg Pasteur Institute, 197101 Saint Petersburg, Russia.
Anna DolgovaSaint Petersburg Pasteur Institute, 197101 Saint Petersburg, Russia.ORCID 0000-0001-8730-4872
Vladimir DedkovSaint Petersburg Pasteur Institute, 197101 Saint Petersburg, Russia.ORCID 0000-0002-5500-0169
Valeriya SbarzagliaSaint Petersburg Pasteur Institute, 197101 Saint Petersburg, Russia.
Olga KanaevaSaint Petersburg Pasteur Institute, 197101 Saint Petersburg, Russia.
Anna PopovaFederal Service for Surveillance on Consumer Rights Protection and Human Well-Being, 127994 Moscow, Russia.
Areg TotolianSaint Petersburg Pasteur Institute, 197101 Saint Petersburg, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic, which began in Wuhan (Hubei, China), has been ongoing for about a year and a half. An unprecedented number of people around the world have been infected with SARS-CoV-2, the etiological agent of COVID-19. Despite the fact that the mortality rate for COVID-19 is relatively low, the total number of deaths has currently already reached more than three million and continues to increase due to high incidence. Since the beginning of the pandemic, a large number of sequences have been obtained and many genetic variants have been identified. Some of them bear significant mutations that affect biological properties of the virus. These genetic variants, currently Variants of Concern (VoC), include the so-called United Kingdom variant (20I/501Y), the Brazilian variant (20J/501Y.V3), and the South African variant (20H/501Y.V2). We describe here a novel SARS-CoV-2 variant with distinct spike protein mutations, first obtained at the end of January 2021 in northwest Russia. Therefore, it is necessary to pay attention to the dynamics of its spread among patients with COVID-19, as well as to study in detail its biological properties.

Indexed as

DNA, ComplementaryDNA Mutational AnalysisGenome, ViralHumansModels, MolecularMutationPhylogenyProtein ConformationRussiaSARS-CoV-2Spike Glycoprotein, CoronavirusDNA, ComplementarySpike Glycoprotein, Coronavirusspike glycoprotein, SARS-CoVCOVID-19northwest (NW) variantRussiaSARS-CoV-2variants of concern

Identifiers

PMID34072569
PMCPMC8230012

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.