Evidence map›Paper›PMID 34072539›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Latticed Gold Nanoparticle Conjugation via Monomeric Streptavidin in Lateral Flow Assay for Detection of Autoantibody to Interferon-Gamma.

Weeraya Thongkum, Umpa Yasamut, Koollawat Chupradit, Supachai Sakkhachornphop, Jiraprapa Wipasa, Kanokporn Sornsuwan, On-Anong Juntit, Rawiwan Pornprasit, Wanwisa Thongkamwitoon, Jirapan Chaichanan and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Weeraya ThongkumDivision of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Umpa YasamutDivision of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0001-9169-7285
Koollawat ChupraditDivision of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Supachai SakkhachornphopCenter of Biomolecular Therapy and Diagnostic, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0002-0419-2201
Jiraprapa WipasaResearch Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Kanokporn SornsuwanDivision of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
On-Anong JuntitDivision of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Rawiwan PornprasitBio Innovation Building, Mahidol University, Nakhon Pathom 73170, Thailand.
Wanwisa ThongkamwitoonBio Innovation Building, Mahidol University, Nakhon Pathom 73170, Thailand.
Jirapan ChaichananBio Innovation Building, Mahidol University, Nakhon Pathom 73170, Thailand.
Jaruwan KhaoplabBio Innovation Building, Mahidol University, Nakhon Pathom 73170, Thailand.
Chonnikarn ChanpradabBio Innovation Building, Mahidol University, Nakhon Pathom 73170, Thailand.
Watchara KasinrerkDivision of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Chatchai TayapiwatanaDivision of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Chiang Mai University · THMahidol University · TH

Funding

the Distinguished Research Professor Grant (NRCT 808/2563) of the National Research Council of Thailand NRCT 808/2563The financial support from Center of Excellence on Medical Biotechnology (CEMB), The S&T Postgraduate Education and Research Development Office (PERDO) SD-63-010-03The Program Management Unit for Human Resources & Institutional development, Research and Innovation (B05F630102) B05F630102
6 · The paper itself

Abstract

Adult-onset immunodeficiency syndrome (AOID) patients with autoantibodies (autoAbs) against interferon-gamma (IFN-γ) generally suffer from recurrent and recalcitrant disseminated non-tuberculous mycobacterial diseases. Since the early stages of AOID do not present specific symptoms, diagnosis and treatment of the condition are not practical. A simplified diagnostic method for differentiating AOID from other immunodeficiencies, such as HIV infection, was created. Anti-IFN-γ is generally identified using enzyme-linked immunosorbent assay (ELISA), which involves an instrument and a cumbersome process. Recombinant IFN-γ indirectly conjugated to colloidal gold was used in the modified immunochromatographic (IC) strips. The biotinylated-IFN-γ was incorporated with colloidal-gold-labeled 6HIS-maltose binding protein-monomeric streptavidin (

Indexed as

anti-interferon-γ autoantibodyconventional indirect ELISAimmunochromatographic strip testinterferon-γ

Identifiers

PMID34072539
PMCPMC8229537
OpenAlexW3164054505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.