Evidence map›Paper›PMID 34072467›Full record

ArticleMolecules (Basel, Switzerland)2021

Structural Insights of Three 2,4-Disubstituted Dihydropyrimidine-5-carbonitriles as Potential Dihydrofolate Reductase Inhibitors.

Lamya H Al-Wahaibi, Althaf Shaik, Mohammed A Elmorsy, Mohammed S M Abdelbaky, Santiago Garcia-Granda, Subbiah Thamotharan, Vijay Thiruvenkatam, Ali A El-Emam

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lamya H Al-WahaibiDepartment of Chemistry, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.
Althaf ShaikDiscipline of Chemistry, Indian Institute of Technology, Gandhinagar 382355, India.ORCID 0000-0003-2571-0714
Mohammed A ElmorsyDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.ORCID 0000-0001-7575-6556
Mohammed S M AbdelbakyDepartment of Physical and Analytical Chemistry, Faculty of Chemistry, Oviedo University-CINN, 33006 Oviedo, Spain.
Santiago Garcia-GrandaDepartment of Physical and Analytical Chemistry, Faculty of Chemistry, Oviedo University-CINN, 33006 Oviedo, Spain.ORCID 0000-0002-2373-0247
Subbiah ThamotharanBiomolecular Crystallography Laboratory, Department of Bioinformatics, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur 613401, India.
Vijay ThiruvenkatamDiscipline of Biological Engineering, Indian Institute of Technology Gandhinagar, Gujarat 382355, India.
Ali A El-EmamDepartment of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.

Funding

Princess Nourah Bint Abdulrahman University No Grant Number
6 · The paper itself

Abstract

In this report, we describe the structural characterization of three 2,4-disubstituted-dihydropyrimidine-5-carbonitrile derivatives, namely 2-{[(4-nitrophenyl)methyl]sulfanyl}-6-oxo-4-propyl-1,6-dihydropyrimidine-5-carbonitrile

Indexed as

Amino Acid MotifsCarbonCatalytic DomainChemistry, PharmaceuticalComputer SimulationDrug DesignFolic Acid AntagonistsHumansHydrogen BondingLigandsMolecular ConformationMolecular Docking SimulationNitrilesProtein ConformationTetrahydrofolate DehydrogenaseWaterCarbonFolic Acid AntagonistsLigandsNitrilesTetrahydrofolate DehydrogenaseWatercrystal structureDFTdihydrofolate reductaseHirshfeld surface analysispyrimidine-5-carbonitriles

Identifiers

PMID34072467
PMCPMC8198998

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.