Evidence map›Paper›PMID 34072433›Full record

ReviewPolymers2021

Zn-Containing Membranes for Guided Bone Regeneration in Dentistry.

Manuel Toledano, Marta Vallecillo-Rivas, María T Osorio, Esther Muñoz-Soto, Manuel Toledano-Osorio, Cristina Vallecillo, Raquel Toledano, Christopher D Lynch, María-Angeles Serrera-Figallo, Raquel Osorio

Abstract readReview
In one paragraph

Review in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Application and prospects of nanomaterials in osteoporosis treatment.International journal of pharmaceutics: X · 2026
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  14. Calcium Phosphate-Based Biomaterials for Bone Repair.Journal of functional biomaterials · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Manuel ToledanoFaculty of Dentistry, University of Granada, Colegio Máximo de Cartuja s/n, 18071 Granada, Spain.
Marta Vallecillo-RivasFaculty of Dentistry, University of Granada, Colegio Máximo de Cartuja s/n, 18071 Granada, Spain.
María T OsorioIndependent research scholar; Av. Fuerzas Armadas n1, 18014 Granada, Spain.
Esther Muñoz-SotoFaculty of Dentistry, University of Granada, Colegio Máximo de Cartuja s/n, 18071 Granada, Spain.
Manuel Toledano-OsorioFaculty of Dentistry, University of Granada, Colegio Máximo de Cartuja s/n, 18071 Granada, Spain.
Cristina VallecilloFaculty of Dentistry, University of Granada, Colegio Máximo de Cartuja s/n, 18071 Granada, Spain.ORCID 0000-0002-4425-2811
Raquel ToledanoIndependent research scholar; Av. Fuerzas Armadas n1, 18014 Granada, Spain.
Christopher D LynchRestorative Dentistry, University Dental School & Hospital, University College Cork, Wilton, T12 E8YV Cork, Ireland.
María-Angeles Serrera-FigalloOral Surgery Section, Faculty of Dentistry, University of Sevilla, Avicena s/n, 41009 Sevilla, Spain.
Raquel OsorioFaculty of Dentistry, University of Granada, Colegio Máximo de Cartuja s/n, 18071 Granada, Spain.

Funding

University of Granada/Regional Government of Andalusia Research Fund from Spain and European Regional Development Fund A-BIO-157-UGR-18/FEDER
6 · The paper itself

Abstract

Barrier membranes are employed in guided bone regeneration (GBR) to facilitate bone in-growth. A bioactive and biomimetic Zn-doped membrane with the ability to participate in bone healing and regeneration is necessary. The aim of the present study is to state the effect of doping the membranes for GBR with zinc compounds in the improvement of bone regeneration. A literature search was conducted using electronic databases, such as PubMed, MEDLINE, DIMDI, Embase, Scopus and Web of Science. A narrative exploratory review was undertaken, focusing on the antibacterial effects, physicochemical and biological properties of Zn-loaded membranes. Bioactivity, bone formation and cytotoxicity were analyzed. Microstructure and mechanical properties of these membranes were also determined. Zn-doped membranes have inhibited in vivo and in vitro bacterial colonization. Zn-alloy and Zn-doped membranes attained good biocompatibility and were found to be non-toxic to cells. The Zn-doped matrices showed feasible mechanical properties, such as flexibility, strength, complex modulus and tan delta. Zn incorporation in polymeric membranes provided the highest regenerative efficiency for bone healing in experimental animals, potentiating osteogenesis, angiogenesis, biological activity and a balanced remodeling. Zn-loaded membranes doped with SiO

Indexed as

antibacterialbioactivitycytotoxicityguided bone regenerationmechanicalmembranesmicroscopyzinc

Identifiers

PMID34072433
PMCPMC8199215

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.