Evidence map›Paper›PMID 34072374›Full record

ArticleSensors (Basel, Switzerland)2021

Plasmonic Sensing Studies of a Gas-Phase Cystic Fibrosis Marker in Moisture Laden Air.

Libin Sun, Douglas Conrad, Drew A Hall, Kurt D Benkstein, Steve Semancik, Mona E Zaghloul

Abstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Libin SunSchool of Engineering and Applied Science, George Washington University, Washington, DC 20052, USA.ORCID 0000-0001-7284-9634
Douglas ConradDepartment of Medicine, University of California, San Diego, CA 92037, USA.
Drew A HallDepartment of Electrical and Computer Engineering, Jacobs School of Engineering, University of California, San Diego, CA 92093, USA.ORCID 0000-0003-0674-074X
Kurt D BenksteinBiomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
Steve SemancikBiomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
Mona E ZaghloulSchool of Engineering and Applied Science, George Washington University, Washington, DC 20052, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A plasmonic sensing platform was developed as a noninvasive method to monitor gas-phase biomarkers related to cystic fibrosis (CF). The nanohole array (NHA) sensing platform is based on localized surface plasmon resonance (LSPR) and offers a rapid data acquisition capability. Among the numerous gas-phase biomarkers that can be used to assess the lung health of CF patients, acetaldehyde was selected for this investigation. Previous research with diverse types of sensing platforms, with materials ranging from metal oxides to 2-D materials, detected gas-phase acetaldehyde with the lowest detection limit at the µmol/mol (parts-per-million (ppm)) level. In contrast, this work presents a plasmonic sensing platform that can approach the nmol/mol (parts-per-billion (ppb)) level, which covers the required concentration range needed to monitor the status of lung infection and find pulmonary exacerbations. During the experimental measurements made by a spectrometer and by a smartphone, the sensing examination was initially performed in a dry air background and then with high relative humidity (RH) as an interferent, which is relevant to exhaled breath. At a room temperature of 23.1 °C, the lowest detection limit for the investigated plasmonic sensing platform under dry air and 72% RH conditions are 250 nmol/mol (ppb) and 1000 nmol/mol (ppb), respectively.

Indexed as

Cystic FibrosisBiomarkersBreath TestsExhalationHumansSurface Plasmon ResonanceBiomarkersacetaldehydecystic fibrosishumidityimage processinglocalized surface plasmon resonanceplasmonic sensing

Identifiers

PMID34072374
PMCPMC8197828

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.