Evidence map›Paper›PMID 34072333›Full record

ArticleInternational journal of molecular sciences2021

Cyclovirobuxine D Induced-Mitophagy through the p65/BNIP3/LC3 Axis Potentiates Its Apoptosis-Inducing Effects in Lung Cancer Cells.

Cheng Zeng, Tingting Zou, Junyan Qu, Xu Chen, Suping Zhang, Zhenghong Lin

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Cheng ZengSchool of Life Sciences, Chongqing University, Chongqing 401331, China.
Tingting ZouSchool of Life Sciences, Chongqing University, Chongqing 401331, China.
Junyan QuSchool of Life Sciences, Chongqing University, Chongqing 401331, China.
Xu ChenSchool of Life Sciences, Chongqing University, Chongqing 401331, China.
Suping ZhangShenzhen Key Laboratory of Precision Medicine for Hematological Malignancies, Department of Pharmacology, Base for International Science and Technology Cooperation: Carson Cancer Stem Cell Vaccines R&D Center, International Cancer Center, Shenzhen University Health Science Center, Shenzhen 518055, China.
Zhenghong LinSchool of Life Sciences, Chongqing University, Chongqing 401331, China.ORCID 0000-0002-6354-0042
Chongqing University · CNShenzhen University Health Science Center · CN

Funding

National Natural Science Foundation of China Grant No. 31571454 to Zhenghong LinNatural Science Foundation Project of CQ CSTC Grant cstc2020jcyj-msxmX0154 to Zhenghong Linthe Shenzhen Basic Research Program JCYJ20180507182203049 to Suping Zhang
6 · The paper itself

Abstract

Mitophagy plays a pro-survival or pro-death role that is cellular-context- and stress-condition-dependent. In this study, we revealed that cyclovirobuxine D (CVB-D), a natural compound derived from

Indexed as

AnimalsAntineoplastic Agents, PhytogenicApoptosisBiomarkersCell Cycle CheckpointsCell Line, TumorDisease Models, AnimalDrugs, Chinese HerbalFluorescent Antibody TechniqueGene Expression RegulationHumansImmunophenotypingLung NeoplasmsMembrane ProteinsMiceMicrotubule-Associated ProteinsAntineoplastic Agents, PhytogenicBiomarkersBNIP3 protein, humancyclovirobuxine DDrugs, Chinese HerbalMAP1LC3A protein, humanMembrane ProteinsMicrotubule-Associated ProteinsProto-Oncogene ProteinsapoptosisBNIP3cyclovirobuxine Dlung cancermitophagy

Identifiers

PMID34072333
PMCPMC8199090
OpenAlexW3164684850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.