Evidence map›Paper›PMID 34072331›Full record

ArticlePolymers2021

Localized Enzyme-Assisted Self-Assembly in the Presence of Hyaluronic Acid for Hybrid Supramolecular Hydrogel Coating.

Jennifer Rodon Fores, Alexis Bigo-Simon, Déborah Wagner, Mathilde Payrastre, Camille Damestoy, Lucille Blandin, Fouzia Boulmedais, Julien Kelber, Marc Schmutz, Morgane Rabineau and 3 more

Abstract read
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jennifer Rodon ForesInstitut Charles Sadron (UPR22), Université de Strasbourg, CNRS, 23 rue du Loess, CEDEX 2, BP 84047, 67034 Strasbourg, France.ORCID 0000-0002-7472-1228
Alexis Bigo-SimonInstitut Charles Sadron (UPR22), Université de Strasbourg, CNRS, 23 rue du Loess, CEDEX 2, BP 84047, 67034 Strasbourg, France.ORCID 0000-0002-7123-4889
Déborah WagnerInstitut Charles Sadron (UPR22), Université de Strasbourg, CNRS, 23 rue du Loess, CEDEX 2, BP 84047, 67034 Strasbourg, France.
Mathilde PayrastreInstitut Charles Sadron (UPR22), Université de Strasbourg, CNRS, 23 rue du Loess, CEDEX 2, BP 84047, 67034 Strasbourg, France.
Camille DamestoyInstitut Charles Sadron (UPR22), Université de Strasbourg, CNRS, 23 rue du Loess, CEDEX 2, BP 84047, 67034 Strasbourg, France.
Lucille BlandinInstitut Charles Sadron (UPR22), Université de Strasbourg, CNRS, 23 rue du Loess, CEDEX 2, BP 84047, 67034 Strasbourg, France.
Fouzia BoulmedaisInstitut Charles Sadron (UPR22), Université de Strasbourg, CNRS, 23 rue du Loess, CEDEX 2, BP 84047, 67034 Strasbourg, France.
Julien KelberInstitut Charles Sadron (UPR22), Université de Strasbourg, CNRS, 23 rue du Loess, CEDEX 2, BP 84047, 67034 Strasbourg, France.
Marc SchmutzInstitut Charles Sadron (UPR22), Université de Strasbourg, CNRS, 23 rue du Loess, CEDEX 2, BP 84047, 67034 Strasbourg, France.ORCID 0000-0003-4059-7609
Morgane RabineauInstitut National de la Santé et de la Recherche Médicale, INSERM Unité 1121, CRBS, 1 rue Eugène Boeckel, CEDEX, 67085 Strasbourg, France.
Miryam Criado-GonzalezInstitut Charles Sadron (UPR22), Université de Strasbourg, CNRS, 23 rue du Loess, CEDEX 2, BP 84047, 67034 Strasbourg, France.ORCID 0000-0002-5502-892X
Pierre SchaafInstitut Charles Sadron (UPR22), Université de Strasbourg, CNRS, 23 rue du Loess, CEDEX 2, BP 84047, 67034 Strasbourg, France.
Loïc JierryInstitut Charles Sadron (UPR22), Université de Strasbourg, CNRS, 23 rue du Loess, CEDEX 2, BP 84047, 67034 Strasbourg, France.ORCID 0000-0002-7541-1360

Funding

Agence Nationale de la Recherche ANR-186CE06-0025-03LabEx Chimie des Systèmes Complexes CSC-PSC-016
6 · The paper itself

Abstract

Hydrogel coating is highly suitable in biomaterial design. It provides biocompatibility and avoids protein adsorption leading to inflammation and rejection of implants. Moreover, hydrogels can be loaded with biologically active compounds. In this field, hyaluronic acid has been largely studied as an additional component since this polysaccharide is naturally present in extracellular matrix. Strategies to direct hydrogelation processes exclusively from the surface using a fully biocompatible approach are rare. Herein we have applied the concept of localized enzyme-assisted self-assembly to direct supramolecular hydrogels in the presence of HA. Based on electronic and fluorescent confocal microscopy, rheological measurements and cell culture investigations, this work highlights the following aspects: (

Indexed as

coatingenzyme-assisted self-assemblyhyaluronic acidpeptidesupramolecular hydrogel

Identifiers

PMID34072331
PMCPMC8198348

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.