ArticleFoods (Basel, Switzerland)2021
Characterization of Relevant Biomarkers for the Diagnosis of Food Allergies: An Overview of the 2S Albumin Family.
Article in Foods (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
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- The "Survivor Peptide" Hypothesis: Structural Resilience and Immunological Persistence of Food Allergens in the Gut-Mammary Axis.Nutrients · 2026Review
- Heat Processing Reduces IgE Binding but Not Basophil Sensitivity to Pea Proteins in Pea-Allergic Children.Nutrients · 2026Article
- Bioactive Properties of Peptides Obtained from the Enzymatic Hydrolysis of Mesquite (Foods (Basel, Switzerland) · 2026Article
- Purification of Prudu6 from Almond and Its Cross-Reactivity with Glym6 from Soybean.International journal of molecular sciences · 2025Article
- Heating Differentiates Pecan Allergen Stability: Car i 4 Is More Heat Labile Than Car i 1 and Car i 2.Food science & nutrition · 2025Article
- Impact of Heat and Pressure Processing Treatments on the Digestibility of Peanut, Hazelnut, Pistachio and Cashew Allergens.Foods (Basel, Switzerland) · 2024Article
- Walnut Jug r 1 is Responsible for Primary Sensitization among Patients Suffering Walnut-Hazelnut 2S Albumin Cross-Reactivity.Journal of agricultural and food chemistry · 2024Article
- Anti-Cancer Properties of Flaxseed Proteome.Proteomes · 2023Review
- Natural History of Hazelnut Allergy and Current Approach to Its Diagnosis and Treatment.Children (Basel, Switzerland) · 2023Review
- Molecular Approaches for Food Protein Allergenicity Assessment and the Diagnosis and Treatment of Food Allergies.Foods (Basel, Switzerland) · 2023Article
- Soy Gly m 8 sIgE Has Limited Value in the Diagnosis of Soy Allergy in Peanut Ara h 2-Sensitized Adults.International archives of allergy and immunology · 2023Article
- Protein fromFood science and biotechnology · 2022Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
2S albumins are relevant and often major allergens from several tree nuts and seeds, affecting mainly children and young people. The present study aims to assess how the structural features of 2S albumins could affect their immunogenic capacity, which is essential to comprehend the role of these proteins in food allergy. For this purpose, twelve 2S albumins were isolated from their respective extracts by chromatographic methods and identified by MALDI-TOF mass-spectrometry. Their molecular and structural characterization was conducted by electrophoretic, spectroscopic and in silico methods, showing that these are small proteins that comprise a wide range of isoelectric points, displaying a general high structure stability to thermal treatment. Despite low amino acid sequence identity, these proteins share structural features, pointing conformational epitopes to explain cross-reactivity between them. Immunoblotting with allergic patients' sera revealed those possible correlations between evolutionarily distant 2S albumins from different sources. The availability of a well-characterized panel of 2S albumins from plant-derived sources allowed establishing correlations between their structural features and their allergenic potential, including their role in cross-reactivity processes.
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