Evidence map›Paper›PMID 34072263›Full record

ArticleVaccines2021

Response to Measles, Mumps and Rubella (MMR) Vaccine in Transfusion-Dependent Patients.

Maddalena Casale, Nicoletta Di Maio, Valentina Verde, Saverio Scianguetta, Maria Grazia Di Girolamo, Rita Tomeo, Domenico Roberti, Saverio Misso, Silverio Perrotta

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Maddalena CasaleDepartment of Women, Child and General and Specialized Surgery, University "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0003-4740-2421
Nicoletta Di MaioDepartment of Women, Child and General and Specialized Surgery, University "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-1224-0242
Valentina VerdeDepartment of Women, Child and General and Specialized Surgery, University "Luigi Vanvitelli", 80138 Naples, Italy.
Saverio ScianguettaDepartment of Women, Child and General and Specialized Surgery, University "Luigi Vanvitelli", 80138 Naples, Italy.
Maria Grazia Di GirolamoImmuno-Transfusion Service, ASL Caserta, 81031 Aversa, Italy.
Rita TomeoImmuno-Transfusion Service, ASL Caserta, 81031 Aversa, Italy.
Domenico RobertiDepartment of Women, Child and General and Specialized Surgery, University "Luigi Vanvitelli", 80138 Naples, Italy.
Saverio MissoImmuno-Transfusion Service, ASL Caserta, 81031 Aversa, Italy.
Silverio PerrottaDepartment of Women, Child and General and Specialized Surgery, University "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0001-6149-6845
Azienda Sanitaria Locale Roma 3 · IT

Funding

American Society of Hematology ASH Global Research Award 2019
6 · The paper itself

Abstract

Measles, mumps and rubella (MMR) still determine significant morbidity and mortality, although a highly effective vaccine is available. Postponing the MMR vaccination until 6 months after the last red blood cell (RBC) transfusion is recommended, but this delay is incompatible with chronic transfusions. The present study aimed at investigating the impact of blood transfusions on the immunogenicity of the MMR vaccine. In this observational study, a group of 45 transfusion- dependent (TD) patients was compared to 24 non-transfusion-dependent (NTD) patients. Immunity to measles was achieved in 35 (78%) TD and 21 (88%) NTD subjects (p = 0.7), to mumps in 36 (80%) TD and 21 (88%) NTD subjects (p = 0.99), and to rubella in 40 (89%) TD and 23 (96%) NTD subjects (p = 0.99). No significant difference was observed in the number of non-immune individuals or those with doubtful protection between the two groups (

Indexed as

live attenuated vaccinemeaslesmumpsred blood cellsrubellatransfusion

Identifiers

PMID34072263
PMCPMC8227230
OpenAlexW3165700182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.