ArticleInternational journal of molecular sciences2021
Fine-Tuning Phylogenetic Alignment and Haplogrouping of mtDNA Sequences.
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed.
- Long-term isolation and archaic introgression shape functional genetic variation in Near Oceania.Science (New York, N.Y.) · 2026Article
- Genomic insights into the admixture history and adaptive evolution of the Zhuang people.Molecular biology and evolution · 2026Article
- Contrasting Maternal, Paternal, and Biparental Ancestry of Populations From the Caribbean Coast of Colombia.American journal of biological anthropology · 2026Article
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- The North African maternal genetic diversity enriched by historical migrations: insights from a comprehensive analysis of complete mitogenomes.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Reduced diversity in human mitogenomes from Eivissa (Balearic Islands).Frontiers in genetics · 2026Article
- Maternal lineage diversity based on mitochondrial DNA in a population sample from Mexico City.Molecular biology reports · 2025Article
- Mitochondrial variation in Taiwan Biobank reveals ancestry structure and trait associations.iScience · 2025Article
- Mitochondrial haplogroup A2 is associated with increased COVID-19 mortality in an admixed Brazilian population.Scientific reports · 2025Article
- Persistence of Ancestral KhoeSan Mitochondrial Patterns in Contemporary South African Populations.Annals of human genetics · 2025Article
- Inherited mitochondrial genetics as a predictor of immune checkpoint inhibition efficacy in melanoma.Nature medicine · 2025Article
- Heterogeneity of the Southeast Belarusian mitochondrial gene pool.Journal of human genetics · 2025Article
- mitoLEAF: mitochondrial DNA Lineage, Evolution, Annotation Framework.NAR genomics and bioinformatics · 2025Article
- Mitochondrial ancestry from complete mitogenomes highlights a lack of characterization of indigenous haplogroups in Brazilian Amazon population.Communications biology · 2025Article
- Comparisons of aged samples and modern references provide algorithm for mtDNA analysis in challenging material.Scientific reports · 2025Article
- The landscape of rare mitochondrial DNA variants in sudden cardiac death: A potential role for ATP synthase.Heliyon · 2025Article
- Kaspar Hauser's alleged noble origin - New molecular genetic analyses resolve the controversy.iScience · 2024Article
- mtDNA "nomenclutter" and its consequences on the interpretation of genetic data.BMC ecology and evolution · 2024Article
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3 authors.
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Abstract
In this paper, we present a new algorithm for alignment and haplogroup estimation of mitochondrial DNA (mtDNA) sequences. Based on 26,011 vetted full mitogenome sequences, we refined the 5435 original haplogroup motifs of Phylotree Build 17 without changing the haplogroup nomenclature. We adapted 430 motifs (about 8%) and added 966 motifs for yet undetermined subclades. In summary, this led to an 18% increase of haplogroup defining motifs for full mitogenomes and a 30% increase for the mtDNA control region that is of interest for a variety of scientific disciplines, such as medical, population and forensic genetics. The new algorithm is implemented in the EMPOP mtDNA database and is freely accessible.
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