Evidence map›Paper›PMID 34072201›Full record

ArticleInternational journal of environmental research and public health2021

Recovery-Stress Response of Blood-Based Biomarkers.

Sebastian Hacker, Thomas Reichel, Anne Hecksteden, Christopher Weyh, Kristina Gebhardt, Mark Pfeiffer, Alexander Ferrauti, Michael Kellmann, Tim Meyer, Karsten Krüger

Abstract read
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sebastian HackerDepartment of Exercise Physiology and Sports Therapy, Institute of Sport Science, Justus-Liebig-University Gießen, 35394 Gießen, Germany.ORCID 0000-0003-1324-9510
Thomas ReichelDepartment of Exercise Physiology and Sports Therapy, Institute of Sport Science, Justus-Liebig-University Gießen, 35394 Gießen, Germany.
Anne HeckstedenInstitute of Sports and Preventive Medicine, Saarland University, 66123 Saarbrücken, Germany.
Christopher WeyhDepartment of Exercise Physiology and Sports Therapy, Institute of Sport Science, Justus-Liebig-University Gießen, 35394 Gießen, Germany.ORCID 0000-0002-4483-7051
Kristina GebhardtDepartment of Exercise Physiology and Sports Therapy, Institute of Sport Science, Justus-Liebig-University Gießen, 35394 Gießen, Germany.
Mark PfeifferInstitute of Sport Science, Johannes Gutenberg University Mainz, 55128 Mainz, Germany.
Alexander FerrautiDepartment of Training & Exercise Science, Faculty of Sport Science, Ruhr University Bochum, 44801 Bochum, Germany.
Michael KellmannUnit of Sport Psychology, Faculty of Sport Science, Ruhr University Bochum, 44801 Bochum, Germany.
Tim MeyerInstitute of Sports and Preventive Medicine, Saarland University, 66123 Saarbrücken, Germany.
Karsten KrügerDepartment of Exercise Physiology and Sports Therapy, Institute of Sport Science, Justus-Liebig-University Gießen, 35394 Gießen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to investigate blood-based biomarkers and their regulation with regard to different recovery-stress states. A total of 35 male elite athletes (13 badminton, 22 soccer players) were recruited, and two venous blood samples were taken: one in a 'recovered' state (REC) after a minimum of one-day rest from exercise and another one in a 'non-recovered' state (NOR) after a habitual loading microcycle. Overall, 23 blood-based biomarkers of different physiologic domains, which address inflammation, muscle damage, and tissue repair, were analyzed by Luminex assays. Across all athletes, only creatine kinase (CK), interleukin (IL-) 6, and IL-17A showed higher concentrations at NOR compared to REC time points. In badminton players, higher levels of CK and IL-17A at NOR were found. In contrast, a higher value for S100 calcium-binding protein A8 (S100A8) at REC was found in badminton players. Similar differences were found for BDNF in soccer players. Soccer players also showed increased levels of CK, and IL-6 at NOR compared to REC state. Several molecular markers were shown to be responsive to differing recovery-stress states, but their suitability as biomarkers in training must be further validated.

Indexed as

SoccerAthletesBiomarkersCreatine KinaseExerciseHumansMaleBiomarkersCreatine Kinasebadmintonchemokinescytokinesmonitoringmuscle damagesoccer

Identifiers

PMID34072201
PMCPMC8199256

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.