Evidence map›Paper›PMID 34072088›Full record

ReviewBiomedicines2021

SARS-CoV-2: One Year in the Pandemic. What Have We Learned, the New Vaccine Era and the Threat of SARS-CoV-2 Variants.

Filippo Scialo, Maria Vitale, Aurora Daniele, Ersilia Nigro, Fabio Perrotta, Monica Gelzo, Carlo Iadevaia, Francesco Saverio Cerqua, Adriano Costigliola, Valentino Allocca and 4 more

Open access · goldAbstract readReview
In one paragraph

Review in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Immune Profile in COVID-19: Unveiling TInternational journal of molecular sciences · 2024
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Bioluminescent and Fluorescent Reporter-Expressing Recombinant SARS-CoV-2.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Filippo ScialoDipartimento di Scienze Mediche Traslazionali, University of Campania "L. Vanvitelli", 80131 Naples, Italy.ORCID 0000-0002-1121-7315
Maria VitaleCEINGE, Biotecnologie Avanzate, 80131 Naples, Italy.ORCID 0000-0002-4399-3132
Aurora DanieleCEINGE, Biotecnologie Avanzate, 80131 Naples, Italy.ORCID 0000-0002-9085-9737
Ersilia NigroCEINGE, Biotecnologie Avanzate, 80131 Naples, Italy.ORCID 0000-0001-5637-1685
Fabio PerrottaU.O.C Pneumologia Azienda Ospedaliera Sant'Anna e San Sebastiano, 81100 Caserta, Italy.
Monica GelzoCEINGE, Biotecnologie Avanzate, 80131 Naples, Italy.ORCID 0000-0002-1500-0746
Carlo IadevaiaPneumology Vanvitelly-COVID Unit A.O. dei Colli Hospital Monaldi, 80131 Naples, Italy.
Francesco Saverio CerquaPneumology Vanvitelly-COVID Unit A.O. dei Colli Hospital Monaldi, 80131 Naples, Italy.
Adriano CostigliolaPneumology Vanvitelly-COVID Unit A.O. dei Colli Hospital Monaldi, 80131 Naples, Italy.
Valentino AlloccaPneumology Vanvitelly-COVID Unit A.O. dei Colli Hospital Monaldi, 80131 Naples, Italy.
Felice AmatoCEINGE, Biotecnologie Avanzate, 80131 Naples, Italy.ORCID 0000-0002-0596-2933
Lucio PastoreCEINGE, Biotecnologie Avanzate, 80131 Naples, Italy.ORCID 0000-0001-6894-9317
Giuseppe CastaldoCEINGE, Biotecnologie Avanzate, 80131 Naples, Italy.
Andrea BiancoDipartimento di Scienze Mediche Traslazionali, University of Campania "L. Vanvitelli", 80131 Naples, Italy.
Ceinge Biotecnologie Avanzate (Italy) · ITOspedale Monaldi · ITUniversity of Campania "Luigi Vanvitelli" · ITOspedale Sant'Anna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the beginning of 2020, the new pandemic caused by SARS-CoV-2 and named coronavirus disease 19 (COVID 19) has changed our socio-economic life. In just a few months, SARS-CoV-2 was able to spread worldwide at an unprecedented speed, causing hundreds of thousands of deaths, especially among the weakest part of the population. Indeed, especially at the beginning of this pandemic, many reports highlighted how people, suffering from other pathologies, such as hypertension, cardiovascular diseases, and diabetes, are more at risk of severe outcomes if infected. Although this pandemic has put the entire academic world to the test, it has also been a year of intense research and many important contributions have advanced our understanding of SARS-CoV-2 origin, its molecular structure and its mechanism of infection. Unfortunately, despite this great effort, we are still a long way from fully understanding how SARS-CoV-2 dysregulates organismal physiology and whether the current vaccines will be able to protect us from possible future pandemics. Here, we discuss the knowledge we have gained during this year and which questions future research should address.

Indexed as

ACE2coronavirusCOVID19kinin-kallikrein systemrenin angiotensin aldosterone systemSARS-CoV-2

Identifiers

PMID34072088
PMCPMC8226851
OpenAlexW3164418285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.